methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate

Base Information

Chemical Name:methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate
CAS No.:1448617-78-4
Molecular Formula:C₃₈H₄₀F₂O₇
Molecular Weight:646.728
Hs Code.:

Synonyms:methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate

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Chemical Property of methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate

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Technology Process of methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate

There total 3 articles about methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1448617-76-2
1-[5-(adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(2-methoxyethoxymethoxy)phenyl]ethan-1-one

: 1571-08-0
methyl 4-formylbenzoate

: 1448617-78-4
methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate

Guidance literature:: methyl 4-formylbenzoate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.5h; Inert atmosphere;

1-[5-(adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(2-methoxyethoxymethoxy)phenyl]ethan-1-one; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 19h; Inert atmosphere;
DOI:10.1002/cmdc.201300100

Reference yield:

: 1-[5-(adamant-1-yl)-2-hydroxy-4-(2-methoxyethoxymethoxy)phenyl]ethan-2-one

: 1448617-78-4
methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 25 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - 0 °C / Inert atmosphere

2.2: 19 h / -78 - 25 °C / Inert atmosphere

With n-butyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300100

Reference yield:

: 141776-91-2
1-bromomethyl-3,5-difluoro-benzene

: 1448617-78-4
methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 25 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - 0 °C / Inert atmosphere

2.2: 19 h / -78 - 25 °C / Inert atmosphere

With n-butyllithium; sodium hydride; diisopropylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300100