(R)-2-benzyloxycarbonylamino-3-[N-(tert-butoxycarbonyl)-N-methyl]amino-1-methanesulfonyloxypropane

Base Information

• Chemical Name: (R)-2-benzyloxycarbonylamino-3-[N-(tert-butoxycarbonyl)-N-methyl]amino-1-methanesulfonyloxypropane
• CAS No.: 1025925-41-0
• Molecular Formula: C₁₈H₂₈N₂O₇S
• Molecular Weight: 416.496
• Mol file: 1025925-41-0.mol

Synonyms:(R)-2-benzyloxycarbonylamino-3-[N-(tert-butoxycarbonyl)-N-methyl]amino-1-methanesulfonyloxypropane

Chemical Property of (R)-2-benzyloxycarbonylamino-3-[N-(tert-butoxycarbonyl)-N-methyl]amino-1-methanesulfonyloxypropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-benzyloxycarbonylamino-3-[N-(tert-butoxycarbonyl)-N-methyl]amino-1-methanesulfonyloxypropane

There total 5 articles about (R)-2-benzyloxycarbonylamino-3-[N-(tert-butoxycarbonyl)-N-methyl]amino-1-methanesulfonyloxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + (R)-2-benzyloxycarbonylamino-3--amino-1-propanol (211992-88-0) → (R)-2-benzyloxycarbonylamino-3-[N-(tert-butoxycarbonyl)-N-methyl]amino-1-methanesulfonyloxypropane (1025925-41-0)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1248/cpb.46.1160

Reference yield:

N-(benzyloxycarbonyl)-L-serine (1145-80-8) → (R)-2-benzyloxycarbonylamino-3-[N-(tert-butoxycarbonyl)-N-methyl]amino-1-methanesulfonyloxypropane (1025925-41-0)

Guidance literature:

Multi-step reaction with 5 steps

1: NaHCO₃ / dimethylformamide / 16 h / Ambient temperature

2: ethanol / 16 h / Ambient temperature

3: 1.) BH₃*THF, 2.) 1N HCl / 1.) THF, RT, 16 h, 2.) THF, reflux, 1 h

4: 94 percent / CHCl₃ / 2 h / Ambient temperature

5: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; borane-THF; sodium hydrogencarbonate; triethylamine; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.1160

Reference yield:

N-benzyloxycarbonyl-L-serine methyl ester (1676-81-9) → (R)-2-benzyloxycarbonylamino-3-[N-(tert-butoxycarbonyl)-N-methyl]amino-1-methanesulfonyloxypropane (1025925-41-0)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 16 h / Ambient temperature

2: 1.) BH₃*THF, 2.) 1N HCl / 1.) THF, RT, 16 h, 2.) THF, reflux, 1 h

3: 94 percent / CHCl₃ / 2 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; borane-THF; triethylamine; In ethanol; dichloromethane; chloroform;

DOI:10.1248/cpb.46.1160

upstream raw materials:

methanesulfonyl chloride

(R)-2-benzyloxycarbonylamino-3--amino-1-propanol

N-(benzyloxycarbonyl)-L-serine

N-benzyloxycarbonyl-L-serine methyl ester