3-(tert-butoxy)-1-(6-methylpyridazin-3-yl)-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one

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Chemical Name:3-(tert-butoxy)-1-(6-methylpyridazin-3-yl)-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one
CAS No.:1384878-25-4
Molecular Formula:C₃₀H₃₀F₃N₃O₄
Molecular Weight:553.581
Hs Code.:

Synonyms:3-(tert-butoxy)-1-(6-methylpyridazin-3-yl)-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one

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Chemical Property of 3-(tert-butoxy)-1-(6-methylpyridazin-3-yl)-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one

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Technology Process of 3-(tert-butoxy)-1-(6-methylpyridazin-3-yl)-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one

There total 3 articles about 3-(tert-butoxy)-1-(6-methylpyridazin-3-yl)-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1260597-59-8
3-hydroxy-4-(4-isopropyl-benzoyl)-1-(6-methyl-pyridazin-3-yl)-5-(4-trifluoromethoxy-phenyl)-1,5-dihydro-pyrrol-2-one

: 1384878-25-4
3-(tert-butoxy)-1-(6-methylpyridazin-3-yl)-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one

Guidance literature:: With triethylamine; dmap; In tert-butyl alcohol; at 60 ℃; for 16h;

Reference yield:

: 852814-99-4
ethyl 4-[4-(1-methylethyl)phenyl]-2,4-dioxobutanoate

: 1384878-25-4
3-(tert-butoxy)-1-(6-methylpyridazin-3-yl)-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / ethanol / 0.25 h / 20 °C

1.2: Reflux

2.1: triethylamine / dmap / tert-butyl alcohol / 16 h / 60 °C

With triethylamine; dmap; acetic acid; In ethanol; tert-butyl alcohol;

Reference yield:

: 645-13-6
4-isopropylacetophenone

: 1384878-25-4
3-(tert-butoxy)-1-(6-methylpyridazin-3-yl)-4-{[4-(propan-2-yl)phenyl]carbonyl}-5-[4-(trifluoromethoxy)phenyl]-2,5-dihydro-1H-pyrrol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; sodium / 0.5 h / 20 °C

1.2: 16 h / Reflux

2.1: acetic acid / ethanol / 0.25 h / 20 °C

2.2: Reflux

3.1: triethylamine / dmap / tert-butyl alcohol / 16 h / 60 °C

With ethanol; sodium; triethylamine; dmap; acetic acid; In ethanol; tert-butyl alcohol;