Technology Process of 17α-(4'-phenylbuta-1',3'-diynyl)estradiol
There total 6 articles about 17α-(4'-phenylbuta-1',3'-diynyl)estradiol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hexylamine hydrochloride; N-butylamine; copper(l) chloride;
In
ethanol;
for 2h;
Yield given;
Ambient temperature;
DOI:10.1016/0039-128X(91)90070-C
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine
2: 76.7 percent / tetramethylethylenediamine, cuprous bromide, Br2, pyridine / tetrahydrofuran / 52 h
3: 67 percent / NaOH, water / CH2Cl2; methanol / 2 h
4: 1.) cuprous chloride, hexylamine hydrochloride, n-butylamine, 2.) hydroxylamine hydrochloride / 1.) 2 min, 2.) ethanol, 10 min
With
pyridine; sodium hydroxide; N,N,N,N,-tetramethylethylenediamine; hydroxylamine hydrochloride; 1-hexylamine hydrochloride; water; bromine; N-butylamine; copper(l) chloride; copper(I) bromide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0039-128X(91)90070-C
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76.7 percent / tetramethylethylenediamine, cuprous bromide, Br2, pyridine / tetrahydrofuran / 52 h
2: 67 percent / NaOH, water / CH2Cl2; methanol / 2 h
3: 1.) cuprous chloride, hexylamine hydrochloride, n-butylamine, 2.) hydroxylamine hydrochloride / 1.) 2 min, 2.) ethanol, 10 min
With
pyridine; sodium hydroxide; N,N,N,N,-tetramethylethylenediamine; hydroxylamine hydrochloride; 1-hexylamine hydrochloride; water; bromine; N-butylamine; copper(l) chloride; copper(I) bromide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0039-128X(91)90070-C
