2-Amino-2-(4-(trifluoromethoxy)phenyl)ethanol

Base Information

• Chemical Name: 2-Amino-2-(4-(trifluoromethoxy)phenyl)ethanol
• CAS No.: 942996-03-4
• Molecular Formula: C₉H₁₀F₃NO₂
• Molecular Weight: 221.179
• European Community (EC) Number: 879-276-7

Synonyms:942996-03-4;2-Amino-2-(4-(trifluoromethoxy)phenyl)ethanol;2-Amino-2-[4-(trifluoromethoxy)phenyl]ethan-1-ol;2-amino-2-[4-(trifluoromethoxy)phenyl]ethanol;2-Amino-2-(4-(trifluoromethoxy)phenyl)ethan-1-ol;SCHEMBL2328155;MFCD11213649;AKOS005266103;BS-9749;CS-0107222;N11178;EN300-1935386

Chemical Property of 2-Amino-2-(4-(trifluoromethoxy)phenyl)ethanol

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 221.06636305
• Heavy Atom Count: 15
• Complexity: 190

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-2-(4-(trifluoromethoxy)phenyl)ethanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(CO)N)OC(F)(F)F

Technology Process of 2-Amino-2-(4-(trifluoromethoxy)phenyl)ethanol

There total 3 articles about 2-Amino-2-(4-(trifluoromethoxy)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-amino-2-(4-(trifluoromethoxy)phenyl)acetic acid (261952-24-3) → 2-amino-2-(4-(trifluoromethoxy)phenyl)ethanol (942996-03-4)

Guidance literature:

With lithium borohydride; sulfuric acid; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

C11H7Cl3F3NO2 → 2-amino-2-(4-(trifluoromethoxy)phenyl)ethanol (942996-03-4)

Guidance literature:

With hydrogenchloride; In methanol; water; for 2h;

DOI:10.1002/anie.202008806

Reference yield:

C11H9Cl3F3NO2 → 2-amino-2-(4-(trifluoromethoxy)phenyl)ethanol (942996-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: cesium iodide; 2,3-dioxaspiro[4.4]nonane-1,4-dione / acetonitrile / 5 h / Irradiation; Inert atmosphere

2: hydrogenchloride / methanol; water / 2 h

With hydrogenchloride; 2,3-dioxaspiro[4.4]nonane-1,4-dione; cesium iodide; In methanol; water; acetonitrile;

DOI:10.1002/anie.202008806

upstream raw materials:

2-amino-2-(4-(trifluoromethoxy)phenyl)acetic acid

Downstream raw materials:

N-(2-hydroxy-1-(4-(trifluoromethoxy)phenyl)ethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide

5-(4-(4-(trifluoromethoxy)phenyl)oxazol-2-yl)pyridin-2(1H)-one

5-(4-(4-(trifluoromethoxy)phenyl)-4,5-dihydrooxazol-2-yl)pyridin-2(1H)-one

N-{2-Hydroxy-1-[4-(trifluoromethoxy)phenyl]ethyl}-1-methyl-5-(4-methylbenzyl)-1H-pyrazole-3-carboxamide

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