21-acetoxy-17α-benzoyloxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Base Information

Chemical Name:21-acetoxy-17α-benzoyloxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione
CAS No.:86413-26-5
Molecular Formula:C₃₁H₃₆O₇
Molecular Weight:520.623
Hs Code.:

Synonyms:21-acetoxy-17α-benzoyloxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 21-acetoxy-17α-benzoyloxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

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Technology Process of 21-acetoxy-17α-benzoyloxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

There total 4 articles about 21-acetoxy-17α-benzoyloxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.8%

: 108-24-7
acetic anhydride

: 86401-96-9
17α-benzoyloxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

: 86413-26-5
21-acetoxy-17α-benzoyloxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Guidance literature:: With triethylamine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1248/cpb.33.1889

Reference yield:

: 86401-96-9
17α-benzoyloxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

: 86413-26-5
21-acetoxy-17α-benzoyloxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Guidance literature:

Reference yield:

: 85198-29-4
6α-methylprednisolone-17α,21-methyl orthobenzoate

: 86413-26-5
21-acetoxy-17α-benzoyloxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 2 N aq. oxalic acid / methanol / 0.17 h / 40 - 45 °C

2: 87.8 percent / Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

With oxalic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1248/cpb.33.1889