2-hydroxy-3-<(4-methoxyphenyl)amino>propanal diethyl acetal

Base Information

• Chemical Name: 2-hydroxy-3-<(4-methoxyphenyl)amino>propanal diethyl acetal
• CAS No.: 148915-92-8
• Molecular Formula: C₁₄H₂₃NO₄
• Molecular Weight: 269.341
• Mol file: 148915-92-8.mol

Synonyms:2-hydroxy-3-<(4-methoxyphenyl)amino>propanal diethyl acetal

Chemical Property of 2-hydroxy-3-<(4-methoxyphenyl)amino>propanal diethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-hydroxy-3-<(4-methoxyphenyl)amino>propanal diethyl acetal

There total 2 articles about 2-hydroxy-3-<(4-methoxyphenyl)amino>propanal diethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2,3-epoxy-1,1-diethoxypropane (13269-77-7) + 4-methoxy-aniline (104-94-9) → 2-hydroxy-3-<(4-methoxyphenyl)amino>propanal diethyl acetal (148915-92-8)

Guidance literature:

at 60 ℃; for 5h;

DOI:10.1021/ja00064a020

Reference yield:

acrylaldehyde diethyl acetal (3054-95-3) → 2-hydroxy-3-<(4-methoxyphenyl)amino>propanal diethyl acetal (148915-92-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / sodium bicarbonate, benzonitrile, aq. 30percent H₂O₂ / methanol / 1.) RT, overnight, 2.) 50 deg C, 5 h

2: 54 percent / 5 h / 60 °C

With dihydrogen peroxide; sodium hydrogencarbonate; benzonitrile; In methanol;

DOI:10.1021/ja00064a020

Reference yield: 93.0%

2-hydroxy-3-<(4-methoxyphenyl)amino>propanal diethyl acetal (148915-92-8) + 1,1'-carbonyldiimidazole (530-62-1) → 5-(diethoxymethyl)-3-(4-methoxyphenyl)-2-oxazolidinone (148915-90-6)

Guidance literature:

In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/ja00064a020

upstream raw materials:

2,3-epoxy-1,1-diethoxypropane

4-methoxy-aniline

acrylaldehyde diethyl acetal

Downstream raw materials:

5-(diethoxymethyl)-3-(4-methoxyphenyl)-2-oxazolidinone