2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester

Base Information

Chemical Name:2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester
CAS No.:635322-34-8
Molecular Formula:C₅₅H₅₄O₁₃
Molecular Weight:923.026
Hs Code.:

2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester

Synonyms:2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester

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Chemical Property of 2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester

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Technology Process of 2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester

There total 6 articles about 2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 635322-32-6
2-{(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-[(2R,4aR,6S,7S,8S,8aR)-8-benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl}-benzoic acid benzyl ester

: 635322-34-8
2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester

Guidance literature:: With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 9h;
DOI:10.1055/s-2003-40348

Reference yield:

: 100-39-0
benzyl bromide

: 635322-34-8
2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Bu₂SnO / methanol / 1 h / Heating

1.2: 84 percent / dimethylformamide / 3 h / 90 °C

2.1: 83 percent / NaH / dimethylformamide / 1.5 h / 20 °C

3.1: 91 percent / H₂; NH₄OAc / Pd/C / methanol / 1 h / 20 °C

4.1: 2,6-di-t-butyl-4-methylpyridine; Tf₂O; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.17 h / -78 °C

4.2: 91 percent / CH₂Cl₂ / 3 h / -78 - 0 °C

5.1: 83 percent / DDQ; H₂O / CH₂Cl₂ / 9 h / 20 °C

With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; 4 A molecular sieve; ammonium acetate; water; hydrogen; sodium hydride; di(n-butyl)tin oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2003-40348

Reference yield:

: 365535-43-9
2'-(benzyloxycarbonyl)benzyl 4,6-O-benzylidene-α-D-mannopyranoside

: 635322-34-8
2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-((2R,4aR,6S,7S,8R,8aR)-8-benzyloxy-7-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Bu₂SnO / methanol / 1 h / Heating

1.2: 84 percent / dimethylformamide / 3 h / 90 °C

2.1: 83 percent / NaH / dimethylformamide / 1.5 h / 20 °C

3.1: 91 percent / H₂; NH₄OAc / Pd/C / methanol / 1 h / 20 °C

4.1: 2,6-di-t-butyl-4-methylpyridine; Tf₂O; 4 Angstroem molecular sieves / CH₂Cl₂ / 0.17 h / -78 °C

4.2: 91 percent / CH₂Cl₂ / 3 h / -78 - 0 °C

5.1: 83 percent / DDQ; H₂O / CH₂Cl₂ / 9 h / 20 °C

With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride; 4 A molecular sieve; ammonium acetate; water; hydrogen; sodium hydride; di(n-butyl)tin oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2003-40348