7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid

Base Information

• Chemical Name: 7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid
• CAS No.: 913987-08-3
• Molecular Formula: C₁₆H₂₆N₂O₇
• Molecular Weight: 358.392
• Mol file: 913987-08-3.mol

Synonyms:7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid

Chemical Property of 7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid

There total 1 articles about 7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → 7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid (913987-08-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / DMAP; DCC

2: 71 percent / NaHMDS / tetrahydrofuran

3: 99 percent / H₂ / Pd/C / tetrahydrofuran / 1.5 h / 20 °C

With dmap; hydrogen; sodium hexamethyldisilazane; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1039/b609446e

Reference yield: 80.0%

7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid (913987-08-3) + O-tritylhydroxylamine (31938-11-1) → [6-oxo-6-(2-oxo-oxazolidin-3-yl)-5-(trityloxycarbamoyl-methyl)-hexyl]-carbamic acid tert-butyl ester (928618-16-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1039/b609446e

Reference yield:

7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid (913987-08-3) → 6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid (913987-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / DCC / CH₂Cl₂

2: 68 percent / LiOH; H₂O₂ / tetrahydrofuran; H₂O

With lithium hydroxide; dihydrogen peroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1039/b609446e

upstream raw materials:

6-(tert-butoxycarbonylamino)hexanoic acid

Downstream raw materials:

[6-oxo-6-(2-oxo-oxazolidin-3-yl)-5-(trityloxycarbamoyl-methyl)-hexyl]-carbamic acid tert-butyl ester

6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid