6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid

Base Information

• Chemical Name: 6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid
• CAS No.: 913987-09-4
• Molecular Formula: C₃₂H₃₈N₂O₆
• Molecular Weight: 546.664
• Mol file: 913987-09-4.mol

Synonyms:6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid

Chemical Property of 6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid

There total 7 articles about 6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

[6-oxo-6-(2-oxo-oxazolidin-3-yl)-5-(trityloxycarbamoyl-methyl)-hexyl]-carbamic acid tert-butyl ester (928618-16-0) → 6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid (913987-09-4)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water;

DOI:10.1039/b609446e

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → 6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid (913987-09-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 65 percent / DMAP; DCC

2: 71 percent / NaHMDS / tetrahydrofuran

3: 99 percent / H₂ / Pd/C / tetrahydrofuran / 1.5 h / 20 °C

4: 80 percent / DCC / CH₂Cl₂

5: 68 percent / LiOH; H₂O₂ / tetrahydrofuran; H₂O

With dmap; lithium hydroxide; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water;

DOI:10.1039/b609446e

Reference yield:

tert-butyl 6-oxo-6-(2-oxooxazolidin-3-yl)hexylcarbamate (913987-07-2) → 6-(tert-butoxycarbonyl)-2-(2-oxo-2-(trityloxyamino)ethyl)hexanoic acid (913987-09-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / NaHMDS / tetrahydrofuran

2: 99 percent / H₂ / Pd/C / tetrahydrofuran / 1.5 h / 20 °C

3: 80 percent / DCC / CH₂Cl₂

4: 68 percent / LiOH; H₂O₂ / tetrahydrofuran; H₂O

With lithium hydroxide; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water;

DOI:10.1039/b609446e

upstream raw materials:

[6-oxo-6-(2-oxo-oxazolidin-3-yl)-5-(trityloxycarbamoyl-methyl)-hexyl]-carbamic acid tert-butyl ester

tert-butyl 6-oxo-6-(2-oxooxazolidin-3-yl)hexylcarbamate

7-(tert-butoxycarbonyl)-3-(2-oxooxazolidine-3-carbonyl)heptanoic acid

7-tert-butoxycarbonylamino-3-(2-oxo-oxazolidine-3-carbonyl)-heptanoic acid benzyl ester