Technology Process of 3-(tert-butoxycarbonyl(isopropyl)amino)-2-(4-chlorophenyl)-2-hydroxypropanoic acid
There total 7 articles about 3-(tert-butoxycarbonyl(isopropyl)amino)-2-(4-chlorophenyl)-2-hydroxypropanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C18H26ClNO5;
With
lithium hydroxide; water;
In
tetrahydrofuran;
at 20 ℃;
for 18h;
Heating / reflux;
With
hydrogenchloride;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sulfuric acid / 20 °C
2: sodium methylate / dimethyl sulfoxide / 2 h / 20 °C
3: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 0 °C
4: 3-chloro-benzenecarboperoxoic acid / chloroform / 24 h / Heating / reflux
5: ethanol / 12 h / 90 °C
6: triethylamine / dichloromethane / 48 h / 20 °C
7: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C / Heating / reflux
With
lithium hydroxide; sulfuric acid; water; sodium methylate; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium methylate / dimethyl sulfoxide / 2 h / 20 °C
2: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 0 °C
3: 3-chloro-benzenecarboperoxoic acid / chloroform / 24 h / Heating / reflux
4: ethanol / 12 h / 90 °C
5: triethylamine / dichloromethane / 48 h / 20 °C
6: lithium hydroxide; water / tetrahydrofuran / 18 h / 20 °C / Heating / reflux
With
lithium hydroxide; water; sodium methylate; methanesulfonyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; dimethyl sulfoxide;
