2,6-Diphenyl-3(2H)-pyridazinone

Base Information

• Chemical Name: 2,6-Diphenyl-3(2H)-pyridazinone
• CAS No.: 28006-42-0
• Molecular Formula: C16H12 N2 O
• Molecular Weight: 248.284
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00502498
• Nikkaji Number: J3.198.502A
• Wikidata: Q82355603
• Mol file: 28006-42-0.mol

Synonyms:28006-42-0;2,6-DIPHENYL-3(2H)-PYRIDAZINONE;2,6-Diphenylpyridazin-3(2H)-one;3(2H)-Pyridazinone,2,6-diphenyl-;SCHEMBL11150434;DTXSID00502498;UKHCFSJQQQJRCA-UHFFFAOYSA-N

Chemical Property of 2,6-Diphenyl-3(2H)-pyridazinone

Chemical Property:

• PSA: 34.89000
• LogP: 2.89950
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 248.094963011
• Heavy Atom Count: 19
• Complexity: 388

Purity/Quality:

99% ^*data from raw suppliers

2,6-DIPHENYL-3(2H)-PYRIDAZINONE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NN(C(=O)C=C2)C3=CC=CC=C3

Technology Process of 2,6-Diphenyl-3(2H)-pyridazinone

There total 15 articles about 2,6-Diphenyl-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

bromobenzene (108-86-1,52753-63-6) + 6-(2-chlorophenyl)-4,5-dihydropyridazin-3(2H)-one (66549-13-1) → 6-oxo-1,3-diphenyl-1,6-dihydropyridazine (28006-42-0)

Guidance literature:

With [N,N'-bis(5-sulfonatosalicylidene)-1,2-diaminoethane]copper disodium salt; sodium carbonate; In water; at 100 ℃; for 12h; Green chemistry;

DOI:10.1021/ol401105x

Reference yield: 95.0%

bromobenzene (108-86-1,52753-63-6) + 6-phenylpyridazin-3(2H)-one (2166-31-6) → 6-oxo-1,3-diphenyl-1,6-dihydropyridazine (28006-42-0)

Guidance literature:

With C₂₀H₁₀Cl₂CuN₂O₈S₂^(2-)*2Na⁽¹⁺⁾; sodium carbonate; In water; at 20 - 80 ℃; for 12h; Sealed tube;

DOI:10.1002/chem.201302495

Reference yield: 92.0%

2,6-diphenyl-4,5-dihydro-3(2H)-pyridazinone (4578-59-0) → 6-oxo-1,3-diphenyl-1,6-dihydropyridazine (28006-42-0)

Guidance literature:

With pyridine; oxygen; copper diacetate; sodium carbonate; In toluene; at 20 - 100 ℃; for 12h; chemoselective reaction;

DOI:10.1002/ejoc.201300640

upstream raw materials:

4-phenyl-4-phenylhydrazono-trans-crotonic acid

acetic anhydride

2,6-diphenyl-4,5-dihydro-3(2H)-pyridazinone

phenylhydrazine

Downstream raw materials:

1-(4-Bromo-phenyl)-2-[2,6-diphenyl-2H-pyridazin-(3E)-ylidene]-ethanone

2,6-diphenyl-2H-pyridazine-3-thione

2,4,6-triphenyl-4,5-dihydro-2H-pyridazin-3-one

2-(4-bromophenyl)-6-phenylpyridazin-3(2H)-one

Refernces

• 1、 Liang, Lei,Wang, Wei,Xu, Fengrong,Niu, Yan,Sun, Qi,Xu, Ping. "Relay catalysis by a multifunctional Cu catalyst in a tandem dehydro-/dehalogenation sequence along with N-arylation". supporting information. p. 2770 - 2773. Retrieved 2013/07/26.
• 2、 Humne, Vivek T.,Konda, Shankaraiah G.,Hasanzadeh, Kamal,Lokhande, Pradeep D.. "Iodine-mediated facile dehydrogenation of dihydropyridazin-3(2H)one". experimental part. p. 1435 - 1438. Retrieved 2012/06/01.