Se-phenyl 1-(methoxymethyl)-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

Base Information

Chemical Name:Se-phenyl 1-(methoxymethyl)-3-[(3-quinolyl)methyl]-2-indolecarboselenoate
CAS No.:879612-38-1
Molecular Formula:C₂₇H₂₂N₂O₂Se
Molecular Weight:485.444
Hs Code.:

Synonyms:Se-phenyl 1-(methoxymethyl)-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

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Chemical Property of Se-phenyl 1-(methoxymethyl)-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

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Technology Process of Se-phenyl 1-(methoxymethyl)-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

There total 7 articles about Se-phenyl 1-(methoxymethyl)-3-[(3-quinolyl)methyl]-2-indolecarboselenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-methoxymethyl-3-quinolin-3-ylmethyl-1H-indole-2-carboxylic acid

: 5707-04-0
Phenylselenyl chloride

: 879612-38-1
Se-phenyl 1-(methoxymethyl)-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

Guidance literature:: 1-methoxymethyl-3-quinolin-3-ylmethyl-1H-indole-2-carboxylic acid; With triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

Phenylselenyl chloride; With tributylphosphine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ol052600e

Reference yield:

: 879612-31-4
methyl 3-formyl-1-(tert-butyloxycarbonyl)-1H-indole-2-carboxylate

: 879612-38-1
Se-phenyl 1-(methoxymethyl)-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi; iPr₂NH / hexane; tetrahydrofuran / -78 - 0 °C

1.2: 65 percent / Et₃SiH; TFA / CH₂Cl₂ / 5 h / 20 °C

2.1: 90 percent / Bu₃SnH; AIBN / benzene / 2 h / Heating

3.1: 90 percent / NaH / tetrahydrofuran / 5 h / 20 °C

4.1: LiOH / tetrahydrofuran; H₂O / 5 h / 65 °C

5.1: Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

5.2: PBu₃ / tetrahydrofuran / 20 °C

With lithium hydroxide; n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; triethylamine; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; water; benzene;
DOI:10.1021/ol052600e

Reference yield:

: 879612-35-8
methyl 3-[(3-quinolyl)methyl]-2-indolecarboxylate

: 879612-38-1
Se-phenyl 1-(methoxymethyl)-3-[(3-quinolyl)methyl]-2-indolecarboselenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / NaH / tetrahydrofuran / 5 h / 20 °C

2.1: LiOH / tetrahydrofuran; H₂O / 5 h / 65 °C

3.1: Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

3.2: PBu₃ / tetrahydrofuran / 20 °C

With lithium hydroxide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol052600e