4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine

Base Information

Chemical Name:4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine
CAS No.:1400815-02-2
Molecular Formula:C₃₄H₃₇N₅O₇
Molecular Weight:627.697
Hs Code.:

Synonyms:4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine

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Technology Process of 4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine

There total 4 articles about 4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₅N₅O₇

: 74-88-4
methyl iodide

: 1400815-02-2
4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine

Guidance literature:: C₃₃H₃₅N₅O₇; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2cc35222b

Reference yield:

: 250708-41-9
1-{2-O-acetyl-5-azido-3-O-benzyl-4-[(benzyloxy)methyl]-5-deoxy-α-L-lyxothranosyl}-5-methylpyrimidine-2,4-(1H,3H)-dione

: 1400815-02-2
4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile; water / 7 h / 0 - 20 °C

2.1: sodium methylate / methanol / 3 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

With sodium methylate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1039/c2cc35222b

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1400815-02-2
4’-C-azidomethyl-3’,5’-di-O-benzyl-3-(4-methoxybenzyl)-2’-O-methylthymidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile; water / 7 h / 0 - 20 °C

2.1: sodium methylate / methanol / 3 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

With sodium methylate; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1039/c2cc35222b