5-(hydroxymethylidene)-2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

Base Information

Chemical Name:5-(hydroxymethylidene)-2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one
CAS No.:1575822-10-4
Molecular Formula:C₂₃H₂₁NO₂
Molecular Weight:343.425
Hs Code.:

Synonyms:5-(hydroxymethylidene)-2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(hydroxymethylidene)-2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

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Technology Process of 5-(hydroxymethylidene)-2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

There total 3 articles about 5-(hydroxymethylidene)-2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1189363-90-3
2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

: 109-94-4
formic acid ethyl ester

: 1575822-10-4
5-(hydroxymethylidene)-2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: 2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one; With potassium tert-butylate; In toluene; at 0 - 20 ℃; for 3h; Inert atmosphere;

formic acid ethyl ester; In toluene; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.10.014

Reference yield:

: 202286-29-1
4-oxo-1-phenyl-4,5,6,7-tetrahydroisoindole

: 1575822-10-4
5-(hydroxymethylidene)-2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 1 h / 0 - 20 °C

2.1: potassium tert-butylate / toluene / 3 h / 0 - 20 °C / Inert atmosphere

2.2: 24 h / 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; toluene; mineral oil;
DOI:10.1016/j.ejmech.2013.10.014

Reference yield:

: 104-82-5
4-Methylbenzyl chloride

: 1575822-10-4
5-(hydroxymethylidene)-2-(4-methylbenzyl)-1-phenyl-2,5,6,7-tetrahydro-4H-isoindol-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

1.2: 1 h / 0 - 20 °C

2.1: potassium tert-butylate / toluene / 3 h / 0 - 20 °C / Inert atmosphere

2.2: 24 h / 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; toluene; mineral oil;
DOI:10.1016/j.ejmech.2013.10.014