(2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate

Base Information

Chemical Name:(2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate
CAS No.:934552-57-5
Molecular Formula:C₁₄H₂₄N₂O₆
Molecular Weight:316.354
Hs Code.:

Synonyms:(2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate

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Chemical Property of (2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate

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Technology Process of (2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate

There total 2 articles about (2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 15761-38-3
L-N-Boc-Ala

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 934552-57-5
(2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 ℃; for 16h;
DOI:10.1016/j.tetasy.2016.12.002

Reference yield:

: 66024-53-1
BOC-Ala-POBT

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 934552-57-5
(2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.bmc.2007.01.020

Reference yield: 78.0%

: 934552-57-5
(2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate

: 748142-27-0
(3S,7R,8aS)-7-hydroxy-3-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: (2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate; With trifluoroacetic acid; In dichloromethane; for 3h;

With triethylamine; In toluene; iso-butanol; for 16h; Reflux;
DOI:10.1016/j.tetasy.2016.12.002