Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-methyl-, (3S,7R,8aR)- (9CI)

Base Information

Chemical Name:Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-methyl-, (3S,7R,8aR)- (9CI)
CAS No.:748142-27-0
Molecular Formula:C₈H₁₂N₂O₃
Molecular Weight:184.195
Hs Code.:
Mol file:748142-27-0.mol

Synonyms:Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-methyl-, (3S,7R,8aR)- (9CI);(3S,7R,8AR)-7-HYDROXY-3-METHYLHEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE

Suppliers and Price of Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-methyl-, (3S,7R,8aR)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-methyl-, (3S,7R,8aR)- (9CI)

Chemical Property:

PSA：73.13000
LogP:-1.31970

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-methyl-, (3S,7R,8aR)- (9CI)

There total 5 articles about Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-7-hydroxy-3-methyl-, (3S,7R,8aR)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 934552-57-5
(2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate

: 748142-27-0
(3S,7R,8aS)-7-hydroxy-3-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: (2'S,4'R)-methyl 1'-((S)-2-tert-butoxycarbonyl)aminopropanoyl-4'-hydroxypyrrolidine-2'-carboxylate; With trifluoroacetic acid; In dichloromethane; for 3h;

With triethylamine; In toluene; iso-butanol; for 16h; Reflux;
DOI:10.1016/j.tetasy.2016.12.002

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 748142-27-0
(3S,7R,8aS)-7-hydroxy-3-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h

2.2: 16 h / Reflux

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tetasy.2016.12.002

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 748142-27-0
(3S,7R,8aS)-7-hydroxy-3-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 12 h / 0 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h

3.2: 16 h / Reflux

With thionyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tetasy.2016.12.002