(2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate

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Chemical Name:(2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate
CAS No.:1267580-01-7
Molecular Formula:C₂₅H₃₃NO₅S₃
Molecular Weight:523.739
Hs Code.:

Synonyms:(2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate

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Chemical Property of (2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate

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Technology Process of (2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate

There total 6 articles about (2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1267579-99-6
(2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1267580-01-7
(2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Cooling with ice; Inert atmosphere;
DOI:10.1002/ejoc.201001211

Reference yield:

: 401564-17-8
(2S,4S)-1-(tert-butoxycarbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid

: 1267580-01-7
(2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: indium(III) chloride / dichloromethane / 24 h / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

3: triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere

With indium(III) chloride; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201001211

Reference yield:

: 1267579-95-2
(2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate

: 1267580-01-7
(2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

2: triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/ejoc.201001211