6-[(4S)-4-phenyl-4,5-dihydro-oxazol-2-yl]-[2,2']bipyridinyl

Base Information

• Chemical Name: 6-[(4S)-4-phenyl-4,5-dihydro-oxazol-2-yl]-[2,2']bipyridinyl
• CAS No.: 915314-13-5
• Molecular Formula: C₁₉H₁₅N₃O
• Molecular Weight: 301.348
• Mol file: 915314-13-5.mol

Synonyms:6-[(4S)-4-phenyl-4,5-dihydro-oxazol-2-yl]-[2,2']bipyridinyl

Chemical Property of 6-[(4S)-4-phenyl-4,5-dihydro-oxazol-2-yl]-[2,2']bipyridinyl

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[(4S)-4-phenyl-4,5-dihydro-oxazol-2-yl]-[2,2']bipyridinyl

There total 1 articles about 6-[(4S)-4-phenyl-4,5-dihydro-oxazol-2-yl]-[2,2']bipyridinyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2,2'-bipyridyl-6-carbonitrile (4392-85-2) + D-2-phenylglycinol (56613-80-0) → 6-[(4S)-4-phenyl-4,5-dihydro-oxazol-2-yl]-[2,2']bipyridinyl (915314-13-5,1666123-70-1)

Guidance literature:

at 130 ℃; for 2h; Microwave irradiation;

DOI:10.1016/j.tetlet.2015.01.182

Reference yield: 59.0%

[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2 (52462-29-0) + 6-[(4S)-4-phenyl-4,5-dihydro-oxazol-2-yl]-[2,2']bipyridinyl (915314-13-5,1666123-70-1) + water (7732-18-5) + sodium dipicolinate → ruthenium [6-[(4S)-4-phenyl-4,5-dihydro-oxazol-2-yl]-[2,2']bipyridinyl](2,6-pyridinedicarboxylate)*H2O

Guidance literature:

In methanol; water; (under Ar); Ru-complex and ligand dissolved in MeOH at room temp., Na-salt dissolved in H2O and MeOH added for 15 min, heated at 65°C for1 h, cooled to room temp., CH2Cl2 and H2O added; organic layer sepd., aq. layer extd. with CH2Cl2, dried over MgSO4, filtered, evapd. under reduced pressure, chromd. on silica gel with CH2Cl2:MeOH 100:3 to 100:7, solvent removed, recrystd. from CH2Cl2/hexane; elem.anal.;

DOI:10.1016/j.jorganchem.2005.12.069

upstream raw materials:

2,2'-bipyridyl-6-carbonitrile

D-2-phenylglycinol