5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine
CAS No.:1312017-32-5
Molecular Formula:C₁₉H₂₁FN₂O₂S
Molecular Weight:360.452
Hs Code.:

Synonyms:5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

There total 6 articles about 5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312017-31-4
5-fluoro-2-[1-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

: 1312017-32-5
5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

: 1312021-23-0
5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: With Daicel IA-H; In hexanes; ethanol; at 25 ℃; Resolution of racemate;

Reference yield:

: 1312019-89-8
toluene-4-sulfonic acid 1-(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-3-methyl-but-1-enyl ester

: 1312017-32-5
5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

: 1312021-23-0
5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 100 °C / Microwave irradiation

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 25 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 50 °C / 2585.81 Torr

4: Daicel IA-H / ethanol; hexanes / 25 °C / Resolution of racemate

With tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; hexanes; ethanol; water;

Reference yield:

: 1312019-90-1
1-benzenesulfonyl-5-fluoro-2-[1-(4-methanesulfonyl-phenyl)-3-methyl-but-1-enyl]-1H-pyrrolo[2,3-b]pyridine

: 1312017-32-5
5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

: 1312021-23-0
5-fluoro-2-[1(R)-(4-methanesulfonyl-phenyl)-3-methyl-butyl]-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 25 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 50 °C / 2585.81 Torr

3: Daicel IA-H / ethanol; hexanes / 25 °C / Resolution of racemate

With tetrabutyl ammonium fluoride; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexanes; ethanol;