(2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate

Base Information

Chemical Name:(2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate
CAS No.:124002-38-6
Molecular Formula:C₂₀H₂₇NO₄
Molecular Weight:345.439
Hs Code.:

Synonyms:(2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate

Suppliers and Price of (2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate

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Chemical Property of (2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate

Chemical Property:

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Technology Process of (2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate

There total 2 articles about (2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 87269-87-2,87679-25-2,88547-79-9,93779-29-4,94569-19-4,138877-09-5
benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride

: 124002-38-6
(2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate

Guidance literature:: benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride; With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

di-tert-butyl dicarbonate; In dichloromethane; at 0 - 30 ℃; for 12h;
DOI:10.1002/anie.201204594

Reference yield: 64.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 93779-31-8
benzyl (1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylate

: 124002-38-6
(2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 124002-38-6
(2S,3aS,6aS)-2-benzyl 1-tert-butyl hexahydrocyclopenta[b]pyrrole-1,2(2H)-dicarboxylate

: 1330784-07-0
tert-butyl (3aS,6aS)-2-{[5-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-2-(methoxycarbonyl)thiophen-3-yl]carbamoyl}hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / 20% palladium hydroxide on activated carbon / methanol / 1 h / 20 °C

2.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / Cooling with ice

2.2: 18 h / 60 °C

With hydrogen; triethylamine; isobutyl chloroformate; 20% palladium hydroxide on activated carbon; In tetrahydrofuran; methanol;