tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

Base Information

Chemical Name:tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate
CAS No.:1330784-09-2
Molecular Formula:C₂₉H₃₃N₅O₃S
Molecular Weight:531.679
Hs Code.:

tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

Synonyms:tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

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Chemical Property of tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

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Technology Process of tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

There total 7 articles about tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87269-87-2,87679-25-2,88547-79-9,93779-29-4,94569-19-4,138877-09-5
benzyl (2S,3AS,6AS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride

: 1330784-09-2
tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

2.1: hydrogen / 20% palladium hydroxide on activated carbon / methanol / 1 h / 20 °C

3.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / Cooling with ice

3.2: 18 h / 60 °C

4.1: sodium hydroxide / water; methanol / 1 h / 60 °C

4.2: Cooling with ice

4.3: 18 h / 80 °C

With hydrogen; triethylamine; sodium hydroxide; isobutyl chloroformate; 20% palladium hydroxide on activated carbon; In tetrahydrofuran; methanol; water;

Reference yield:

: 1330784-07-0
tert-butyl (3aS,6aS)-2-{[5-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-2-(methoxycarbonyl)thiophen-3-yl]carbamoyl}hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

: 1330784-09-2
tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

Guidance literature:: tert-butyl (3aS,6aS)-2-{[5-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-2-(methoxycarbonyl)thiophen-3-yl]carbamoyl}hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate; With sodium hydroxide; In methanol; water; at 60 ℃; for 1h;

With hydrogenchloride; In methanol; water; Cooling with ice;

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1330784-09-2
tert-butyl (3aS,6aS)-2-[6-(1-benzyl-3-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl]hexahydrocyclopenta[b]pyrrole-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

2.1: hydrogen / 20% palladium hydroxide on activated carbon / methanol / 1 h / 20 °C

3.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 1 h / Cooling with ice

3.2: 18 h / 60 °C

4.1: sodium hydroxide / water; methanol / 1 h / 60 °C

4.2: Cooling with ice

4.3: 18 h / 80 °C

With hydrogen; triethylamine; sodium hydroxide; isobutyl chloroformate; 20% palladium hydroxide on activated carbon; In tetrahydrofuran; methanol; water;