N-{1-[(2R,3R,3aR,9aR)-3-(2-Hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Base Information

• Chemical Name: N-{1-[(2R,3R,3aR,9aR)-3-(2-Hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
• CAS No.: 176747-29-8
• Molecular Formula: C₃₀H₄₇N₃O₈Si₂
• Molecular Weight: 633.889

Synonyms:N-{1-[(2R,3R,3aR,9aR)-3-(2-Hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Chemical Property of N-{1-[(2R,3R,3aR,9aR)-3-(2-Hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Chemical Property:

Purity/Quality:

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Technology Process of N-{1-[(2R,3R,3aR,9aR)-3-(2-Hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

There total 3 articles about N-{1-[(2R,3R,3aR,9aR)-3-(2-Hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-{2-Oxo-1-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(2-oxo-ethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1,2-dihydro-pyrimidin-4-yl}-benzamide (176747-28-7) → N-{1-[(2R,3R,3aR,9aR)-3-(2-Hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide (176747-29-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 90h; Ambient temperature;

DOI:10.1021/ja960091t

Reference yield:

N-[1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide → N-{1-[(2R,3R,3aR,9aR)-3-(2-Hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide (176747-29-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / N-methylmorpholine N-oxide, aq. OsO₄ / acetone / 2.5 h / Ambient temperature

2: 97 percent / aq. NaIO₄ / dioxane / 4.5 h / Ambient temperature

3: 93 percent / NaBH₄ / methanol / 90 h / Ambient temperature

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide; In 1,4-dioxane; methanol; acetone;

DOI:10.1021/ja960091t

Reference yield:

N-{1-[(2R,3R,3aR,9aR)-3-(2,3-Dihydroxy-propoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide (176747-26-5) → N-{1-[(2R,3R,3aR,9aR)-3-(2-Hydroxy-ethoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide (176747-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / aq. NaIO₄ / dioxane / 4.5 h / Ambient temperature

2: 93 percent / NaBH₄ / methanol / 90 h / Ambient temperature

With sodium tetrahydroborate; sodium periodate; In 1,4-dioxane; methanol;

DOI:10.1021/ja960091t

upstream raw materials:

N-{2-Oxo-1-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(2-oxo-ethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1,2-dihydro-pyrimidin-4-yl}-benzamide

N-{1-[(2R,3R,3aR,9aR)-3-(2,3-Dihydroxy-propoxy)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Downstream raw materials:

N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Thiobenzoic acid S-{2-[(2R,3R,3aR,9aR)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yloxy]-ethyl} ester

Thiobenzoic acid S-{2-[(2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yloxy]-ethyl} ester

N-{1-[(2R,3R,4R,5R)-3-(2-tert-Butyldisulfanyl-ethoxy)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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