(SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine

Base Information

Chemical Name:(SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine
CAS No.:108035-52-5
Molecular Formula:C₂₅H₃₅O₂P
Molecular Weight:398.525
Hs Code.:

Synonyms:(SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine

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Chemical Property of (SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine

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Technology Process of (SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine

There total 6 articles about (SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 108035-56-9
(SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine oxide

: 108035-52-5
(SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine

Guidance literature:: With diethyl-cyclohexyl-amine; trichlorosilane; In acetonitrile; for 1h; Ambient temperature;
DOI:10.1021/jo00387a010

Reference yield:

: 2216-51-5
(-)-menthol

: 108035-52-5
(SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / NaH / 14 h / 60 °C

2: 92 percent / trichlorosilane, cyclohexyldiethylamine / acetonitrile / 1 h / Ambient temperature

With diethyl-cyclohexyl-amine; trichlorosilane; sodium hydride; In acetonitrile;
DOI:10.1021/jo00387a010

Reference yield:

: 20663-35-8
(S_p)-(2-methoxyphenyl)methylphenylphosphine oxide

: 108035-52-5
(SP,1'R,2'S,5'R)-<2-<(2'-isopropyl-5'-methylcyclohexyl)oxy>ethyl>(o-methoxyphenyl)phenylphosphine

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / LDA, CuCl₂ / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h, 2.) RT, 0.5 h

2: 82 percent / xylene / 1 h / Heating

3: 81 percent / NaH / 14 h / 60 °C

4: 92 percent / trichlorosilane, cyclohexyldiethylamine / acetonitrile / 1 h / Ambient temperature

With diethyl-cyclohexyl-amine; trichlorosilane; sodium hydride; copper dichloride; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile; xylene;
DOI:10.1021/jo00387a010