3-(4-BROMOBENZOYL)ACRYLIC ACID

Base Information

• Chemical Name: 3-(4-BROMOBENZOYL)ACRYLIC ACID
• CAS No.: 39644-80-9
• Molecular Formula: C10H7 Br O3
• Molecular Weight: 255.068
• Hs Code.: 2918300090
• Mol file: 39644-80-9.mol

Synonyms:Acrylicacid, 3-(p-bromobenzoyl)- (7CI); 3-(4-Bromobenzoyl)acrylic acid;3-(p-Bromobenzoyl)acrylic acid; 4-(4-bromophenyl)-4-oxo-2-butenoic acid;4-Bromobenzoylacrylic acid

Chemical Property of 3-(4-BROMOBENZOYL)ACRYLIC ACID

Chemical Property:

• Melting Point: 152-154°C
• PSA: 54.37000
• LogP: 2.27260

Purity/Quality:

99% ^*data from raw suppliers

(2E)-4-(4-Bromophenyl)-4-oxobut-2-enoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-BROMOBENZOYL)ACRYLIC ACID

There total 6 articles about 3-(4-BROMOBENZOYL)ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

maleic anhydride (108-31-6) + bromobenzene (108-86-1,52753-63-6) → β-(4-bromobenzoyl)acrylic acid (39644-80-9)

Guidance literature:

With aluminum (III) chloride; Cooling with ice; Reflux;

Reference yield:

p-bromobenzoylmethylenetriphenylphosphorane (1777-57-7) → β-(4-bromobenzoyl)acrylic acid (39644-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene

2: aq. HCl, AcOH / Heating

With hydrogenchloride; acetic acid; In benzene;

Reference yield:

para-bromophenacyl bromide (99-73-0,132309-76-3) → β-(4-bromobenzoyl)acrylic acid (39644-80-9)

Guidance literature:

Multi-step reaction with 4 steps

1: benzene / Heating

2: NaOEt / ethanol; CHCl₃

3: benzene

4: aq. HCl, AcOH / Heating

With hydrogenchloride; sodium ethanolate; acetic acid; In ethanol; chloroform; benzene;

upstream raw materials:

(Z)-4-(4-Bromo-phenyl)-4-oxo-but-2-enoic acid ethyl ester

p-bromobenzoylmethylenetriphenylphosphorane

para-bromophenacyl bromide

maleic anhydride

Downstream raw materials:

4-(4-bromophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid

β-(4-bromobenzoyl)-α-(3,4-xylyl)propionic acid

β-(4-bromobenzoyl)-α-(2,5-xylyl)propionic acid

β-(p-bromobenzoyl)-α-(diphenylphosphoryl)propionic acid

Refernces

• 1、 Rizk,Attia,Osman, Doaa I.,Nessim. "Synthesis and applications of pyridazinones for base oil improvement". . p. 129 - 146. Retrieved 2017/06/13.
• 2、 Wang, Shasha,Hu, Lijuan,Cheng, Suyan,Wang, Lanzhi. "Synthesis of 1,5-benzodiazepine derivatives using p-toluenesulfonic acid as catalyst". . p. 419 - 424. Retrieved 2015/01/30.