1777-57-7

Basic information

• Product Name: 1-(4-bromophenyl)-2-(triphenyl-lambda~5~-phosphanylidene)ethanone
• CAS NO: 1777-57-7
• Molecular Formula: C₂₆H₂₀BrOP
• Molecular Weight: 459.3142
• Mol File: 1777-57-7.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 592.7°C at 760 mmHg
• Flash Point: 312.2°C
• Density: 1.37g/cm³
• Vapor Pressure: 5.1E-14mmHg at 25°C
• Refractive Index: 1.668
• CAS DataBase Reference: 1-(4-bromophenyl)-2-(triphenyl-lambda~5~-phosphanylidene)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-2-(triphenyl-lambda~5~-phosphanylidene)ethanone(1777-57-7)
• EPA Substance Registry System: 1-(4-bromophenyl)-2-(triphenyl-lambda~5~-phosphanylidene)ethanone(1777-57-7)

Safety Data

• Hazardous Substances Data: 1777-57-7(Hazardous Substances Data)

Usage

General Description

1-(4-bromophenyl)-2-(triphenyl-lambda5-phosphanylidene)ethanone is a chemical compound with the molecular formula C22H18BrOP. It is an organophosphorus compound that contains a phosphorus atom bonded to three phenyl groups and an ethanone group with a bromophenyl substituent. 1-(4-bromophenyl)-2-(triphenyl-lambda~5~-phosphanylidene)ethanone is used in organic synthesis and can act as a reagent in various chemical reactions. Its structure and properties make it useful in the development of new pharmaceuticals and as a building block for more complex organic molecules. Additionally, it may have potential applications in the field of materials science and as a precursor for the synthesis of other phosphorus-containing compounds.

Upstream product

• 35497-00-8 Triphenyl-β-keto-p-bromphenylphosphonium 
• 99-73-0 para-bromophenacyl bromide 
• 603-35-0 triphenylphosphine 
• 99-90-1 para-bromoacetophenone 
• 2928-58-7 (2-oxo-2-p-bromophenylethyl)triphenylphosphonium bromide 

Downstream Products

• 86453-75-0 (E)-3-(p-Brombenzoylmethylen)-4,4-dimethyl-2-oxo-tetrahydrofuran 
• 86453-76-1 (Z)-3-(p-Brombenzoylmethylen)-4,4-dimethyl-2-oxo-tetrahydrofuran 
• 5301-98-4 5-(4-bromophenyl)-1H-1,2,3-triazole 
• 791-28-6 Triphenylphosphine oxide 
• 254453-91-3 p-(2-thienyl)benzoylmethylidenetriphenylphosphorane 
• 39644-80-9 β-(4-bromobenzoyl)acrylic acid 
• 1190719-39-1 (E)-1-(4-bromophenyl)-4-((1-methyl-1H-indol-2-yl)methoxy)but-2-en-1-one 
• 1189060-07-8 ethyl (E,E)-6-(4-bromophenyl)-6-oxohexa-2,4-dienoate 
• 5471-96-5 (E)-1,3-bis(4-bromophenyl)prop-2-en-1-one 
• 1287312-90-6 [Pd{κ²(C,C)-[(C₆H₄-2)PPh₂]CH(CO)C₆H₄Br-4}(μ-Cl)]₂ 
• 22731-70-0 1-(4-bromophenyl)prop-2-en-1-one 
• 1256284-92-0 1-(4-bromophenyl)-2-(9-methyl-2,3,4,9-tetrahydro-1H-carbazol-4-yl)ethanone 
• 1393118-17-6 2-((4R,6S)-4-benzyl-1-phenyl-3-(trifluoromethyl)-1,4,5,6-tetrahydropyrano[2,3-c]pyrazol-6-yl)-1-(4-bromophenyl)ethanone 
• 1393118-19-8 1-(4-bromophenyl)-2-((4R,6S)-1,4-dimethyl-3-(trifluoromethyl)-1,4,5,6-tetrahydropyrano[2,3-c]pyrazol-6-yl)ethanone 

Relevant articles and documents

Oxygen- versus carbon-coordination of the alpha-stabilized phosphorus ylide Ph3P=C(H)R in palladacycles bearing secondary amines

The ortho-metalated complex [Pd(x){κ 2 (C,N)-[C 6H4CH2NRR′ (Y)}] (2a-4a and 2b-3b) was prepared by refluxing in benzene equimolecular amounts of Pd(OAc)2 and secondary benzylamine [a, EtNHCH2/su

Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions

The development of non-natural reaction mechanisms is an attractive strategy for expanding the synthetic capabilities of substrate promiscuous enzymes. Here, we report an "ene"-reductase catalyzed asymmetric hydroalkylation of olefins using α-bromoketones as radical precursors. Radical initiation occurs via ground-state electron transfer from the flavin cofactor located within the enzyme active site, an underrepresented mechanism in flavin biocatalysis. Four rounds of site saturation mutagenesis were used to access a variant of the "ene"-reductase nicotinamide-dependent cyclohexanone reductase (NCR) from Zymomonas mobiles capable of catalyzing a cyclization to furnish β-chiral cyclopentanones with high levels of enantioselectivity. Additionally, wild-type NCR can catalyze intermolecular couplings with precise stereochemical control over the radical termination step. This report highlights the utility for ground-state electron transfers to enable non-natural biocatalytic C-C bond forming reactions.

One-pot synthesis of new hydantoin (thiohydantoin) derivatives and evaluation of their antibacterial and antioxidant activities

One-pot four-component reactions of phenacyl bromides, parabanic or thioparabanic acids, thiophenols, and triphenylphosphine in the presence of triethylamine afforded new derivatives of hydantoin or thiohydantoin in good to high yields (65%-90%). Their an