(3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol

Base Information

• Chemical Name: (3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol
• CAS No.: 91418-95-0
• Molecular Formula: C₃₁H₅₆O₃
• Molecular Weight: 476.784
• Mol file: 91418-95-0.mol

Synonyms:(3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol

Chemical Property of (3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol

There total 39 articles about (3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl magnesium iodide (917-64-6) + (7R,11R)-1-(2,5-dimethoxy-3,4,6-trimethylphenyl)-7,11,15-trimethylhexadecan-3-one → (3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol (91418-95-0)

Guidance literature:

(7R,11R)-1-(2,5-dimethoxy-3,4,6-trimethylphenyl)-7,11,15-trimethylhexadecan-3-one; With C₂₄H₄₂N₂O; In toluene; at 20 ℃; for 0.0833333h; Schlenk technique;

methyl magnesium iodide; In diethyl ether; toluene; at -78 ℃; Schlenk technique;

DOI:10.1002/anie.201610462

Reference yield:

(3R,7R)-3,7,11-trimethyl-dodecyl bromide (65528-01-0) + (S)-4-(2,5-Dimethoxy-3,4,6-trimethylphenyl)-1,2-epoxy-2-methylbutan (96203-95-1) + copper(I) 2-propylacetylide → (3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol (91418-95-0)

Guidance literature:

With ammonium chloride; In diethyl ether; chloroform;

Reference yield:

Durohydroquinone (527-18-4) → (3R,7R,11R)-1-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-3,7,11,15-tetramethyl-hexadecan-3-ol (91418-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 50percent NaOH / Bu₄NBr / toluene / Ambient temperature

2: KOtBu, BuLi / tetrahydrofuran / 0.5 h / Ambient temperature

3: tetrahydrofuran / 16 h / Ambient temperature

With sodium hydroxide; n-butyllithium; potassium tert-butylate; tetrabutylammomium bromide; In tetrahydrofuran; toluene;

DOI:10.1002/hlca.19900730431

upstream raw materials:

(3R,7R)-3,7,11-Trimethyldodecylmagnesium-bromid

(S)-4-(2,5-Dimethoxy-3,4,6-trimethylphenyl)-1,2-epoxy-2-methylbutan

(2R,6R,10R)-1,2-Epoxy-2,6,10,14-tetramethylpentadecan

Durohydroquinone

Downstream raw materials:

2-[(3R,7R,11R)-3-hydroxy-3,7,11,15-tetramethylhexadecyl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione

Tocopherol

2-((7R,11R)-3-Hydroxy-3,7,11,15-tetramethylhexadecyl)-3,5,6-trimethylbenzene-1,4-diol