3-ethyl-5-[5-mercapto-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Base Information

Chemical Name:3-ethyl-5-[5-mercapto-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol
CAS No.:1464138-38-2
Molecular Formula:C₂₁H₂₂N₆O₂S
Molecular Weight:422.511
Hs Code.:

Synonyms:3-ethyl-5-[5-mercapto-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

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Chemical Property of 3-ethyl-5-[5-mercapto-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

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Technology Process of 3-ethyl-5-[5-mercapto-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

There total 6 articles about 3-ethyl-5-[5-mercapto-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-hydroxy-3-ethyl-1H-indazole-5-carboxylic acid N-(4-morpholinophenyl)thiosemicarbazide

: 1464138-38-2
3-ethyl-5-[5-mercapto-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Guidance literature:: With potassium hydroxide; In water; at 80 ℃; for 1h;

Reference yield:

: 1464139-84-1
6-hydroxy-3-ethyl-1H-indazole-5-carboxylic acid hydrazide

: 1464138-38-2
3-ethyl-5-[5-mercapto-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: potassium hydroxide / water / 1 h / 80 °C

With potassium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 1583-58-0
2,4-difluoro-benzoic acid

: 1464138-38-2
3-ethyl-5-[5-mercapto-4-(4-morpholin-4-yl-phenyl)-4H-[1,2,4]triazol-3-yl]-1H-indazol-6-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C

2.1: sulfuric acid / Reflux

3.1: aluminum (III) chloride / dichloromethane / 0.08 h

3.2: Reflux

4.1: hydrazine / ethanol / Reflux

5.1: tetrahydrofuran / 20 °C

6.1: potassium hydroxide / water / 1 h / 80 °C

With aluminum (III) chloride; sulfuric acid; potassium hydroxide; sodium hydroxide; hydrazine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water;