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2,4-Difluorobenzoic acid
Cas No: 1583-58-0
USD $ 1.0-1.0 / Gram 1 Gram 500 Kilogram/Year Xiamen Jenny Chemical Technology Co., Ltd. Contact Supplier
2,4-Difluorobenzoic acid
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High quality 2,4-Difluorobenzoic acid and derivatives supplier in China
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1583-58-0 2,4-Difluorobenzoic acid
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high quality cas 1583-58-0 2,4-Difluorobenzoic acid
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1583-58-0 Usage

Chemical Properties

white to light yellow crystal powder

Uses

2,4-Difluorobenzoic Acid (cas# 1583-58-0) is a compound useful in organic synthesis.

General Description

Molecular conformation, vibrational and electronic transition analysis of 2,4-difluorobenzoic acid has been investigated by experimental techniques (FT-IR, FT-Raman and UV) and quantum chemical calculations.
InChI:InChI=1/C7H4F2O2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,(H,10,11)/p-1

1583-58-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A13403)  2,4-Difluorobenzoic acid, 98%    1583-58-0 5g 288.0CNY Detail
Alfa Aesar (A13403)  2,4-Difluorobenzoic acid, 98%    1583-58-0 25g 1121.0CNY Detail
Alfa Aesar (A13403)  2,4-Difluorobenzoic acid, 98%    1583-58-0 100g 3852.0CNY Detail

1583-58-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,4-Difluorobenzoic acid

1.2 Other means of identification

Product number -
Other names 2,4-Difluor-benzoesaeure

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1583-58-0 SDS

1583-58-0Synthetic route

2,4-difluoro-3-(triethylsilyl)benzoic acid
651027-06-4

2,4-difluoro-3-(triethylsilyl)benzoic acid

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water for 2h; Heating;98%
N-(4-cyanophenyl)-2,4-difluorobenzamide

N-(4-cyanophenyl)-2,4-difluorobenzamide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With hydrogenchloride at 80℃; for 18h;98%
2,4-difluoro-6-bromo-isopropylbenzene

2,4-difluoro-6-bromo-isopropylbenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With 1,3-Dichloro-2-propanol; boron trifluoride diethyl etherate; water at 50℃; for 1.83333h; Temperature;97%
carbon dioxide
124-38-9

carbon dioxide

2,4-difluoro-1-iodobenzene
2265-93-2

2,4-difluoro-1-iodobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -75℃;92%
Stage #1: 2,4-difluoro-1-iodobenzene With copper In tetrahydrofuran at 25℃; for 0.5h;
Stage #2: carbon dioxide In tetrahydrofuran for 24h;
76%
2,4-difluorobenzonitrile
3939-09-1

2,4-difluorobenzonitrile

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With 1-butyl-3-methylimidazolium hydrogen sulfate; water at 60 - 65℃; for 2.5h; Green chemistry;92%
2,4-difluoroethynylbenzene
302912-34-1

2,4-difluoroethynylbenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate; nickel dibromide at 120℃; under 760.051 Torr; for 48h;92%
2,4-difluoro-3-chlorobenzoic acid
154257-75-7

2,4-difluoro-3-chlorobenzoic acid

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With sodium hydroxide; zinc for 2h; Heating;91%
2,4-difluorophenyl 2,3,4,5,6-pentafluorobenzenesulfonate

2,4-difluorophenyl 2,3,4,5,6-pentafluorobenzenesulfonate

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;90%
formic acid
64-18-6

formic acid

2,4-difluoro-1-iodobenzene
2265-93-2

2,4-difluoro-1-iodobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere; Sealed tube;87%
2',4'-difluoroacetophenone
364-83-0

2',4'-difluoroacetophenone

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With oxygen; manganese (II) acetate tetrahydrate; cobalt(II) diacetate tetrahydrate; acetic acid at 180℃; under 18751.9 Torr; for 1.5h; Reagent/catalyst; Temperature; Green chemistry;85%
With sodium percarbonate; potassium tert-butylate; sphingosylphosphorylcholine; meta-dinitrobenzene In tert-butyl alcohol at 80℃; for 5h;23%
With potassium permanganate Oxidation;
2,4-difluorophenyl trifluoromethanesulfonate

2,4-difluorophenyl trifluoromethanesulfonate

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;82%
2,4-dinitrobenzoic acid
610-30-0

2,4-dinitrobenzoic acid

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With potassium fluoride; cetyltrimethylammonim bromide In N,N-dimethyl-formamide at 120℃; for 7h;72.4%
2,4-difluorotoluene
452-76-6

2,4-difluorotoluene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With potassium permanganate
2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

carbon dioxide
124-38-9

carbon dioxide

A

3-bromo-2,6-difluorobenzoic acid
28314-81-0

3-bromo-2,6-difluorobenzoic acid

B

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

C

2,6-difluorobenzoic acid
385-00-2

2,6-difluorobenzoic acid

Conditions
ConditionsYield
With n-butyllithium 1) hexane, Et2O, 2 min, -78 deg C. 2) ether; Yield given. Multistep reaction. Yields of byproduct given;
With n-butyllithium 1) hexane, THF; 2 min, -78 deg C. 2) ether; Yield given. Multistep reaction. Yields of byproduct given;
4-Fluorobenzoic acid
456-22-4

4-Fluorobenzoic acid

A

2,3,4,5-tetrafluorobenzoic acid
1201-31-6

2,3,4,5-tetrafluorobenzoic acid

B

3,4-Difluorobenzoic acid
455-86-7

3,4-Difluorobenzoic acid

C

2,4,5-trifluorobenzoic acid
446-17-3

2,4,5-trifluorobenzoic acid

D

2,3,4,-trifluorobenzoic acid
61079-72-9

2,3,4,-trifluorobenzoic acid

E

3,4,5-trifluorobenzoic acid
121602-93-5

3,4,5-trifluorobenzoic acid

F

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With fluorine In sulfuric acid Product distribution; various substrate to fluorine ratios; also in 98percent HCOOH;
2,4-difluorobenzaldehyde
1550-35-2

2,4-difluorobenzaldehyde

A

2,4-difluorophenol
367-27-1

2,4-difluorophenol

B

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With 4-hydroxyacetophenone monooxygenase from P. fluorescens ACB; oxygen; NADPH In phosphate buffer at 30℃; for 1h; pH=8.0; Enzyme kinetics; Baeyer-Villiger oxidation;
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: BuLi / hexane; tetrahydrofuran / 0.75 h / -75 °C
1.2: 74 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane / 0.75 h / -75 °C
2.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: 90 percent / tetrahydrofuran; hexane
3.1: 91 percent / Zn; aq. NaOH / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 89 percent / butyllithium / hexane; tetrahydrofuran / -75 °C
2: 89 percent / sec-butyllithium / cyclohexane; tetrahydrofuran / 0.75 h
3: 98 percent / potassium hydroxide / ethanol; H2O / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 98 percent / sec-BuLi; I2 / tetrahydrofuran; cyclohexane / -75 °C
2: 48 percent / LDA / tetrahydrofuran; hexane / -75 °C
3: 92 percent / BuLi / tetrahydrofuran; hexane / -75 °C
View Scheme
Multi-step reaction with 2 steps
2: KMnO4
View Scheme
1-chloro-2,6-difluorobenzene
38361-37-4

1-chloro-2,6-difluorobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C
1.2: 90 percent / tetrahydrofuran; hexane
2.1: 91 percent / Zn; aq. NaOH / 2 h / Heating
View Scheme
1-triethylsilyl-2,6-difluorobenzene
651027-02-0

1-triethylsilyl-2,6-difluorobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / sec-butyllithium / cyclohexane; tetrahydrofuran / 0.75 h
2: 98 percent / potassium hydroxide / ethanol; H2O / 2 h / Heating
View Scheme
2,6-difluoroiodobenzene
13697-89-7

2,6-difluoroiodobenzene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 48 percent / LDA / tetrahydrofuran; hexane / -75 °C
2: 92 percent / BuLi / tetrahydrofuran; hexane / -75 °C
View Scheme
phenylhydrazine hydrochloride
59-88-1

phenylhydrazine hydrochloride

2,4-difluorobenzoyl chloride
72482-64-5

2,4-difluorobenzoyl chloride

A

benzoic acid hydrazide
613-94-5

benzoic acid hydrazide

B

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
In pyridineA 98 g (79%)
B n/a
C22H18F2O4

C22H18F2O4

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
In ethanol; dichloromethane at 25℃; Kinetics;
2,4-difluorophenol
367-27-1

2,4-difluorophenol

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane; water / 16 h / 20 °C / Schlenk technique; Inert atmosphere
View Scheme
2,4-difluorophenylcarbonylmethylenetriphenylphosphine

2,4-difluorophenylcarbonylmethylenetriphenylphosphine

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
With dihydrogen peroxide In tetrahydrofuran at 50℃; for 18h; Inert atmosphere;
2,4-dinitrotoluene
121-14-2

2,4-dinitrotoluene

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Stage #1: 2,4-dinitrotoluene With ammonium chloride In ethanol at 75 - 85℃; for 1.16667h;
Stage #2: With manganese(IV) oxide; tetrabutylammomium bromide; dihydrogen peroxide at 40 - 60℃; for 1h;
Stage #3: With tetrabutylammomium bromide; sodium fluoride In N,N-dimethyl-formamide at 100 - 115℃; for 5.5h;
3,5-dichloro-N-(4-cyanophenyl)-2,4,6-trifluorobenzamide

3,5-dichloro-N-(4-cyanophenyl)-2,4,6-trifluorobenzamide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; tris[2-phenylpyridinato-C2,N]iridium(III) / acetonitrile / 48 h / 60 °C / Sealed tube; Inert atmosphere; Photolysis
2: hydrogenchloride / 18 h / 80 °C
View Scheme
3,5-dichloro-2,4,6-trifluorobenzoyl chloride

3,5-dichloro-2,4,6-trifluorobenzoyl chloride

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; tris[2-phenylpyridinato-C2,N]iridium(III) / acetonitrile / 48 h / 60 °C / Sealed tube; Inert atmosphere; Photolysis
3: hydrogenchloride / 18 h / 80 °C
View Scheme
2,4,6-trifluoro-3,5-dichlorobenzoic acid
13656-36-5

2,4,6-trifluoro-3,5-dichlorobenzoic acid

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / 4 h / 70 °C
2: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C
3: N-ethyl-N,N-diisopropylamine; tris[2-phenylpyridinato-C2,N]iridium(III) / acetonitrile / 48 h / 60 °C / Sealed tube; Inert atmosphere; Photolysis
4: hydrogenchloride / 18 h / 80 °C
View Scheme
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluorobenzoyl chloride
72482-64-5

2,4-difluorobenzoyl chloride

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere; Cooling with ice;100%
Stage #1: 2,4-difluoro-benzoic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h;
Stage #2: With oxalyl dichloride In dichloromethane at 20℃; for 12h;
100%
With thionyl chloride Heating;96%
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluoro-5-iodobenzoic acid

2,4-difluoro-5-iodobenzoic acid

Conditions
ConditionsYield
With N-iodo-succinimide; sulfuric acid at 0℃; for 4h;100%
With N-iodo-succinimide; trifluorormethanesulfonic acid at 5 - 50℃; for 1.5h; Product distribution / selectivity;100%
With N-Iodosuccinamide; sulfuric acid at 0 - 5℃; for 5h;94%
(2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester
869489-00-9

(2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

(2S,4S)-4-[4-(2,4-difluorobenzoyl)piperazin-1-yl]-2-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4S)-4-[4-(2,4-difluorobenzoyl)piperazin-1-yl]-2-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: (2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester; 2,4-difluoro-benzoic acid With O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water
100%
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluoro-5-nitro-benzoic acid
153775-33-8

2,4-difluoro-5-nitro-benzoic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 0 - 20℃; for 16.5h;98%
With sulfuric acid; nitric acid In water at 20 - 50℃; for 3.5h;98%
With sulfuric acid; nitric acid at 0 - 20℃; for 16.5h;98%
3,4,5-Trimethoxyaniline
24313-88-0

3,4,5-Trimethoxyaniline

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluoro-N-(3,4,5-trimethoxyphenyl)benzamide

2,4-difluoro-N-(3,4,5-trimethoxyphenyl)benzamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;98%
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

methyl 2,4-difluorobenzoate
106614-28-2

methyl 2,4-difluorobenzoate

Conditions
ConditionsYield
With thionyl chloride In methanol97%
Multi-step reaction with 2 steps
1: thionyl chloride; sulfuric acid / 0.2 h / Inert atmosphere; Reflux
2: triethylamine / dichloromethane / 0 °C / Inert atmosphere
View Scheme
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

4-fluorosalicylic acid
345-29-9

4-fluorosalicylic acid

Conditions
ConditionsYield
With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide at 130℃; for 4h;95.1%
With sodium hydroxide In dimethyl sulfoxide at 130℃; for 8h;90%
With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide at 135℃; for 4h;68%
With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide at 135℃; for 6h;67.52%
With sodium hydroxide In 1-methyl-pyrrolidin-2-one at 150℃; for 1h;
benzo[1,3]dioxolo-5-ylamine
14268-66-7

benzo[1,3]dioxolo-5-ylamine

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

N-(benzo[d][1,3]dioxol-5-yl)-2,4-difluorobenzamide

N-(benzo[d][1,3]dioxol-5-yl)-2,4-difluorobenzamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;93%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2,4-difluoro-N-(4-methoxyphenyl)benzamide

2,4-difluoro-N-(4-methoxyphenyl)benzamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;93%
2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

3-fluorophenol
372-20-3

3-fluorophenol

Conditions
ConditionsYield
With water; sodium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 170 - 175℃; for 15h; Sealed tube;92.8%
3,4-dimethoxyaniline
6315-89-5

3,4-dimethoxyaniline

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

N-(3,4-dimethoxyphenyl)-2,4-difluorobenzamide

N-(3,4-dimethoxyphenyl)-2,4-difluorobenzamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;91%
methyl (L)-leucinate hydrochloride
7517-19-3

methyl (L)-leucinate hydrochloride

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

(S)-methyl 2-(2,4-difluorobenzamido)-4-methylpentanoate

(S)-methyl 2-(2,4-difluorobenzamido)-4-methylpentanoate

Conditions
ConditionsYield
With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;90%
europium(III) hydroxide

europium(III) hydroxide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

C21H13EuF6O8

C21H13EuF6O8

Conditions
ConditionsYield
In methanol; acetone at 60℃; for 1h;89%
tert-butyl alcohol
75-65-0

tert-butyl alcohol

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

tert-butyl 2,4-difluorobenzoate
500353-15-1

tert-butyl 2,4-difluorobenzoate

Conditions
ConditionsYield
With dmap; di-tert-butyl dicarbonate for 48h;86%
With dmap; di-tert-butyl dicarbonate at 20℃; for 24h;84%
With dmap; di-tert-butyl dicarbonate In dichloromethane at 20℃; for 24h;84%
ethanol
64-17-5

ethanol

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

ethyl 2,4-di-fluorobenzoate
108928-00-3

ethyl 2,4-di-fluorobenzoate

Conditions
ConditionsYield
With sulfuric acid for 3h; Heating;85%
With hydrogenchloride at 80℃; for 24.25h;76%
Stage #1: ethanol; 2,4-difluoro-benzoic acid With hydrogenchloride for 5.33333h; Heating / reflux;
Stage #2: With sodium hydroxide In diethyl ether; water
With hydrogenchloride
With sulfuric acid Heating;
3,5-dimethylphenyl iodide
22445-41-6

3,5-dimethylphenyl iodide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

3,5-difluoro-3',5'-dimethyl-1,1'-biphenyl
1344681-47-5

3,5-difluoro-3',5'-dimethyl-1,1'-biphenyl

Conditions
ConditionsYield
With palladium diacetate; acetic acid; silver carbonate at 130℃; for 16h; regioselective reaction;85%
5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole-3-carbohydrazide

5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole-3-carbohydrazide

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

2-(5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-3-yl)-5-(2,4-difluorophenyl)-1,3,4-oxadiazole

2-(5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-3-yl)-5-(2,4-difluorophenyl)-1,3,4-oxadiazole

Conditions
ConditionsYield
With trichlorophosphate Reflux;85%
ethyl 3-(dimethylamino)acrylate
924-99-2, 1117-37-9, 114894-59-6

ethyl 3-(dimethylamino)acrylate

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

(Z)-ethyl 2-(2,4-difluorobenzoyl)-3-(dimethylamino)acrylate

(Z)-ethyl 2-(2,4-difluorobenzoyl)-3-(dimethylamino)acrylate

Conditions
ConditionsYield
Stage #1: 2,4-difluoro-benzoic acid With thionyl chloride at 80℃; for 2h;
Stage #2: ethyl 3-(dimethylamino)acrylate With triethylamine In toluene at 90℃; for 12h;
85%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl alcohol
75-65-0

tert-butyl alcohol

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

tert-butyl 2,4-difluorobenzoate
500353-15-1

tert-butyl 2,4-difluorobenzoate

Conditions
ConditionsYield
dmap In dichloromethane at 20℃; for 24h;84%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2,4-difluoro-benzoic acid
1583-58-0

2,4-difluoro-benzoic acid

tert-butyl 2,4-difluorobenzoate
500353-15-1

tert-butyl 2,4-difluorobenzoate

Conditions
ConditionsYield
With dmap In dichloromethane; tert-butyl alcohol at 20℃; for 24h;84%
dmap In tert-butyl alcohol at 40℃; for 18h;81%
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