3-(tert-butyldimethylsilyloxymethyl)-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole

Base Information

Chemical Name:3-(tert-butyldimethylsilyloxymethyl)-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole
CAS No.:331242-52-5
Molecular Formula:C₂₉H₄₃NO₃Si₂
Molecular Weight:509.836
Hs Code.:

Synonyms:3-(tert-butyldimethylsilyloxymethyl)-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(tert-butyldimethylsilyloxymethyl)-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole

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Technology Process of 3-(tert-butyldimethylsilyloxymethyl)-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole

There total 1 articles about 3-(tert-butyldimethylsilyloxymethyl)-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 153168-61-7
3-<<oxy>methyl>-5-isoxazolepropanol

: 331242-52-5
3-(tert-butyldimethylsilyloxymethyl)-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1071/CH03295

Reference yield: 91.0%

: 331242-52-5
3-(tert-butyldimethylsilyloxymethyl)-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole

: 156787-23-4
5-<3-<<(dimethylethyl)diphenylsilyl>oxy>propyl>-3-isoxazolemethanol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran;
DOI:10.1071/CH03295

Reference yield:

: 331242-52-5
3-(tert-butyldimethylsilyloxymethyl)-5-[3-(tert-butyldiphenylsilyloxy)propyl]isoxazole

: C₄₄H₅₀F₆N₆O₁₁

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / aq. HCl / tetrahydrofuran

2: 75 percent / PPh₃; Br₂

3: NaH; Bu₄NI / tetrahydrofuran

4: Bu₄NF / tetrahydrofuran

5: diisopropyl azodicarboxylate; PPh₃ / diethyl ether / 0 - 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; bromine; tetra-(n-butyl)ammonium iodide; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; 5: Mitsunobu reaction;
DOI:10.1071/CH03295