N'-[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]-4-methoxybenzene-1,3-diamine

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Chemical Name:N'-[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]-4-methoxybenzene-1,3-diamine
CAS No.:1453198-92-9
Molecular Formula:C₁₉H₁₆ClN₅O
Molecular Weight:365.822
Hs Code.:

Synonyms:N'-[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]-4-methoxybenzene-1,3-diamine

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Chemical Property of N'-[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]-4-methoxybenzene-1,3-diamine

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Technology Process of N'-[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]-4-methoxybenzene-1,3-diamine

There total 2 articles about N'-[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]-4-methoxybenzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937366-57-9
3-(2,5-dichloropyrimidine-4-yl)-1H-indole

: 1453198-92-9
N'-[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]-4-methoxybenzene-1,3-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 24 h / 120 °C

2: ammonium chloride; iron / ethanol; water / 3 h / Reflux

With iron; ammonium chloride; toluene-4-sulfonic acid; In ethanol; water;
DOI:10.1021/jm400822z

Reference yield:

: 120-72-9
indole

: 1453198-92-9
N'-[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]-4-methoxybenzene-1,3-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: methylmagnesium bromide / 2-methyltetrahydrofuran; tetrahydrofuran / 0.5 h / 0 - 2 °C

1.2: 2.5 h / 60 °C / Cooling with ice

2.1: toluene-4-sulfonic acid / 24 h / 120 °C

3.1: ammonium chloride; iron / ethanol; water / 3 h / Reflux

With methylmagnesium bromide; iron; ammonium chloride; toluene-4-sulfonic acid; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; water;
DOI:10.1021/jm400822z