3-(2,5-dichloropyrimidin-4-yl)-1H-indole

Base Information

Chemical Name:3-(2,5-dichloropyrimidin-4-yl)-1H-indole
CAS No.:937366-57-9
Molecular Formula:C12H7Cl2N3
Molecular Weight:264.114
Hs Code.:2933990090
Mol file:937366-57-9.mol

Synonyms:3-(2,5-dichloropyriMidin-4-yl)-1H-indole;1H-Indole, 3-(2,5-dichloro-4-pyrimidinyl)-

Suppliers and Price of 3-(2,5-dichloropyrimidin-4-yl)-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-(2,5-Dichloropyrimidin-4-yl)-1H-indole 95+%
1g
$ 772.00

Chemenu
3-(2,5-dichloropyrimidin-4-yl)-1H-indole 95%
1g
$ 729.00

American Custom Chemicals Corporation
3-(2,5-DICHLOROPYRIMIDIN-4-YL)-1H-INDOLE 95.00%
5MG
$ 503.33

AK Scientific
3-(2,5-Dichloropyrimidin-4-yl)-1H-indole
1g
$ 1313.60

Total 16 raw suppliers

Chemical Property of 3-(2,5-dichloropyrimidin-4-yl)-1H-indole

Chemical Property:

PSA：41.57000
LogP:3.93170
Storage Temp.:Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

3-(2,5-Dichloropyrimidin-4-yl)-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-(2,5-Dichloropyrimidin-4-yl)-1H-indole is used in the preparation 2-(2,4,5-substituted -anilino)pyrimidine derivatives as EGFR modulators useful for the prevention or treatment of a number of different cancers, in particular non-small cell lung cancer.

Technology Process of 3-(2,5-dichloropyrimidin-4-yl)-1H-indole

There total 5 articles about 3-(2,5-dichloropyrimidin-4-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 120-72-9
indole

: 5750-76-5
2,4,5-trichloropyrimidine

: 937366-57-9
3-(2,5-dichloropyrimidine-4-yl)-1H-indole

Guidance literature:: 2,4,5-trichloropyrimidine; With aluminum (III) chloride; In 1,2-dichloro-ethane; at 80 ℃; for 0.5h; Inert atmosphere;

indole; In 1,2-dichloro-ethane; at 80 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c01171

Reference yield: 75.0%

: 882562-40-5
3-(2,5-dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole

: 937366-57-9
3-(2,5-dichloropyrimidine-4-yl)-1H-indole

Guidance literature:: With water; sodium hydroxide; In 1,4-dioxane; at 75 ℃; for 3h;

Reference yield:

: 129271-98-3
1-(phenylsulfonyl)-1H-indol-3-ylboronic acid

: 937366-57-9
3-(2,5-dichloropyrimidine-4-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂CO₃ / Pd(PPh₃)4 / acetonitrile; H₂O / 1.5 h / Heating

2: KOH / methanol / 0.5 h / Heating

With potassium hydroxide; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; acetonitrile; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2007.03.078