1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester

Base Information

• Chemical Name: 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester
• CAS No.: 940868-17-7
• Molecular Formula: C14H18N2O3
• Molecular Weight: 262.30
• Hs Code.: 2933399090
• Mol file: 940868-17-7.mol

Synonyms:2-Carbamoylpiperidine-1-carboxylic acid benzyl ester;

Chemical Property of 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester

Chemical Property:

• Vapor Pressure: 3.3E-09mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 475.495 °C at 760 mmHg
• Flash Point: 241.371 °C
• PSA: 72.63000
• Density: 1.224 g/cm³
• LogP: 2.30120

Purity/Quality:

99%, ^*data from raw suppliers

Benzyl2-Carbamoylpiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester

There total 4 articles about 1-Piperidinecarboxylic acid, 2-(aminocarbonyl)-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-(carbobenzyloxy)-2-piperidinecarboxylic acid (28697-11-2) + isobutyl chloroformate (543-27-1) → benzyl 2-(aminocarbonyl)piperidine-1-carboxylate (940868-17-7)

Guidance literature:

With ammonia; triethylamine; In ethyl acetate;

Reference yield:

N-benzyloxycarbonyl D/L-pipecolinic acid (28697-07-6) → benzyl 2-(aminocarbonyl)piperidine-1-carboxylate (940868-17-7)

Guidance literature:

With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/jm070027u

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → benzyl 2-(aminocarbonyl)piperidine-1-carboxylate (940868-17-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / H₂O / 20 °C

2: NH₃; EDCI; HOBt / dioxane / 20 °C

With ammonia; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; water;

DOI:10.1021/jm070027u

upstream raw materials:

N-benzyloxycarbonyl D/L-pipecolinic acid

benzyl chloroformate

pipecolic Acid

(S)-1-(carbobenzyloxy)-2-piperidinecarboxylic acid

Downstream raw materials:

benzyl 2-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)piperidine-1-carboxylate

N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide

benzyl 2-[(Z)-amino(hydroxyimino)methyl]piperidine-1-carboxylate

2-cyanopiperidine-1-carboxylic acid benzyl ester

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