N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide

Base Information

• Chemical Name: N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide
• CAS No.: 519028-92-3
• Molecular Formula: C₁₇H₁₉FN₄O₃
• Molecular Weight: 346.361
• Mol file: 519028-92-3.mol

Synonyms:N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide

Chemical Property of N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide

There total 11 articles about N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 2-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)piperidine-1-carboxylate (519028-71-8) → N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide (519028-92-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jm070027u DOI:10.1021/jm060854f

Reference yield:

benzyl 2-[(Z)-amino(hydroxyimino)methyl]piperidine-1-carboxylate (940868-21-3,940931-23-7) → N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide (519028-92-3)

Guidance literature:

Multi-step reaction with 4 steps

1: CHCl₃ / 60 °C

2: xylene / 3 h / Heating

3: dimethylformamide / 90 °C

4: H₂ / Pd/C / methanol / 1 h / 20 °C

With hydrogen; palladium on activated charcoal; In methanol; chloroform; N,N-dimethyl-formamide; xylene;

DOI:10.1021/jm070027u

Reference yield:

2-(1-benzyloxycarbonyl-piperidin-2-yl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid methyl ester → N-(4-fluorobenzyl)-5,6-dihydroxy-2-piperidin-2-ylpyrimidine-4-carboxamide (519028-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 90 °C

2: H₂ / Pd/C / methanol / 1 h / 20 °C

With hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm070027u DOI:10.1021/jm060854f

upstream raw materials:

benzyl 2-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)piperidine-1-carboxylate

2-cyanopiperidine-1-carboxylic acid benzyl ester

benzyl 2-(aminocarbonyl)piperidine-1-carboxylate

benzyl 2-[(Z)-amino(hydroxyimino)methyl]piperidine-1-carboxylate

Downstream raw materials:

C₂₃H₂₄FN₅O₄S

C₁₉H₂₁FN₄O₄