2,2,2-trichloroethyl (S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-2-enylcarbamate

Base Information

Chemical Name:2,2,2-trichloroethyl (S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-2-enylcarbamate
CAS No.:864875-41-2
Molecular Formula:C₃₀H₄₀Cl₃NO₅Si
Molecular Weight:629.096
Hs Code.:

Synonyms:2,2,2-trichloroethyl (S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-2-enylcarbamate

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Chemical Property of 2,2,2-trichloroethyl (S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-2-enylcarbamate

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Technology Process of 2,2,2-trichloroethyl (S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-2-enylcarbamate

There total 5 articles about 2,2,2-trichloroethyl (S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-2-enylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-3-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylaldehyde

: 864875-41-2
2,2,2-trichloroethyl (S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-2-enylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / chiral Soai catalyst / cyclohexane / 0 - 20 °C

2: CH₂Cl₂

3: aq. K₂CO₃ / methanol

4: PPh₃; CBr₄; Et₃N / CH₂Cl₂ / -40 °C

5: 20 °C

With carbon tetrabromide; chiral Soai catalyst; potassium carbonate; triethylamine; triphenylphosphine; In methanol; dichloromethane; cyclohexane;
DOI:10.1002/anie.200500892

Reference yield:

: 864875-39-8
(S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-1-en-3-ol

: 864875-41-2
2,2,2-trichloroethyl (S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-2-enylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂

2: aq. K₂CO₃ / methanol

3: PPh₃; CBr₄; Et₃N / CH₂Cl₂ / -40 °C

4: 20 °C

With carbon tetrabromide; potassium carbonate; triethylamine; triphenylphosphine; In methanol; dichloromethane;
DOI:10.1002/anie.200500892

Reference yield:

: 864875-40-1
(E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-1-en-3-yl carbamate

: 864875-41-2
2,2,2-trichloroethyl (S,E)-1-((4R,5R)-5-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)pent-2-enylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: PPh₃; CBr₄; Et₃N / CH₂Cl₂ / -40 °C

2: 20 °C

With carbon tetrabromide; triethylamine; triphenylphosphine; In dichloromethane;
DOI:10.1002/anie.200500892