Chemical Property of 2,2,2-Trichloroethanol
Chemical Property:
- Appearance/Colour:Clear colourless to light yellow liquid
- Vapor Pressure:1 mm Hg ( 20 °C)
- Melting Point:17.8 °C(lit.)
- Refractive Index:n20/D 1.49(lit.)
- Boiling Point:152.066 °C at 760 mmHg
- PKA:12.24(at 25℃)
- Flash Point:45.768 °C
- PSA：20.23000
- Density:1.602 g/cm3
- LogP:1.34890
- Storage Temp.:Store below +30°C.
- Sensitive.:Hygroscopic
- Solubility.:83g/l
- Water Solubility.:Slightly soluble in water.
- XLogP3:1.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:0
- Exact Mass:147.924948
- Heavy Atom Count:6
- Complexity:38.5
- Purity/Quality:
-
99% *data from raw suppliers
2,2,2-Trichloroethanol *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-41-67
- Safety Statements:
26-39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Other Classes -> Halogenated Alcohols
- Canonical SMILES:C(C(Cl)(Cl)Cl)O
-
Uses
Intermediate, anesthetic. 2,2,2-Trichloroethanol (TCE) is an active metabolite of Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] (T774055), a sedative/hypnotic that increases cerebral blood flow (CBF). The 2,2,2-Trichloroethyl (TCE) moiety of 2,2,2-trichloroethanol is mainly used as a protecting group for acids, acetals and also phosphoryl groups of nucleotides. It can be easily cleaved by zinc reduction.Some of its other application include:Conversion of per-O-acetylated sugars to per-O-acetylated trichloroethyl derivatives.Preparation of TCE ester of chlorosulfuric acid.Preparation of 2,2,2-trichloroethyl acetimidate hydrochloride.
