tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate)

Base Information

Chemical Name:tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate)
CAS No.:1345983-61-0
Molecular Formula:C₃₃H₅₄N₂O₉P₂S
Molecular Weight:716.813
Hs Code.:

tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate)

Synonyms:tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate)

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Chemical Property of tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate)

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Technology Process of tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate)

There total 6 articles about tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1345983-53-0
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine trifluoroacetate salt

: 762-04-9
phosphonic acid diethyl ester

: 1345983-61-0
tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate)

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 75 ℃;
DOI:10.1021/jm400459m

Reference yield: 18.6%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1345983-52-9
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine

: 762-04-9
phosphonic acid diethyl ester

: 1345983-61-0
tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate)

Guidance literature:: formaldehyd; {[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine; toluene-4-sulfonic acid; In toluene; at 75 ℃; for 0.5h;

phosphonic acid diethyl ester; In toluene; for 0.5h;

In tetrahydrofuran; toluene; at 75 ℃;

Reference yield:

: 1345983-39-2
(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl trifluoromethanesulfonate

: 1345983-61-0
tetraethyl [({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}imino)dimethanediyl]bis(phosphonate)

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl-formamide / 0.25 h / 25 °C / Inert atmosphere

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 2068.65 Torr

3: toluene-4-sulfonic acid / toluene / 75 °C

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; zinc; In ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm400459m