10-chloro-1,2-dimethyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

Base Information

Chemical Name:10-chloro-1,2-dimethyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole
CAS No.:1022956-89-3
Molecular Formula:C₁₉H₁₉ClN₂O₃S
Molecular Weight:390.89
Hs Code.:

Synonyms:10-chloro-1,2-dimethyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

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Chemical Property of 10-chloro-1,2-dimethyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

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Technology Process of 10-chloro-1,2-dimethyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

There total 6 articles about 10-chloro-1,2-dimethyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1022956-84-8
10-chloro-1-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

: 1022956-89-3
10-chloro-1,2-dimethyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

Guidance literature:: formaldehyd; 10-chloro-1-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole; In tetrahydrofuran; water; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; water; for 0.5h;

Reference yield:

: 1022956-70-2
tert-butyl 1-methyl-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole-2-carboxylate

: 1022956-89-3
10-chloro-1,2-dimethyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / tetrahydrofuran / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.1: trifluoroacetic acid / N,N-dimethyl-formamide

3.2: 0.17 h

4.1: tetrahydrofuran; water / 0.17 h / 20 °C

4.2: 0.5 h

With N-chloro-succinimide; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1022955-37-8
1-methyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

: 1022956-89-3
10-chloro-1,2-dimethyl-8-(phenylsulfonyl)-1,3,4,8-tetrahydro-2H-[1,4]oxazepino[6,7-e]indole

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 20 °C

2.1: sodium hydroxide; water / ethanol / 2 h / 70 °C

3.1: N-chloro-succinimide / tetrahydrofuran / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.1: trifluoroacetic acid / N,N-dimethyl-formamide

5.2: 0.17 h

6.1: tetrahydrofuran; water / 0.17 h / 20 °C

6.2: 0.5 h

With sodium hydroxide; N-chloro-succinimide; water; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;