Technology Process of 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine 1,1-dioxide
There total 13 articles about 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine 1,1-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 80 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: chlorosulfonic acid / 16.5 h / 0 - 20 °C
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: boron tribromide / dichloromethane / 0.5 h / 20 °C
3.2: Cooling with ice
4.1: triethylamine / dimethylaminopyridine / dichloromethane / 20 °C
5.1: potassium carbonate; ethanol / potassium iodide / 18 h / Reflux
6.1: dmap / dichloromethane / 20 °C
7.1: n-butyllithium / tetrahydrofuran / 2 h / -65 - 20 °C
7.2: Cooling with ice
8.1: pyridine; copper diacetate; oxygen / dichloromethane / 20 h / 20 °C / Molecular sieve
9.1: hydrogenchloride / 1,4-dioxane / 2 h / 80 °C
With
pyridine; hydrogenchloride; chlorosulfonic acid; n-butyllithium; ethanol; oxygen; copper diacetate; boron tribromide; potassium carbonate; triethylamine;
dmap; potassium iodide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 20 °C
2: toluene-4-sulfonic acid / toluene / 12 h / Reflux
3: hydrogenchloride; water / 1.5 h / Reflux
4: pyridine; copper diacetate; oxygen / dichloromethane / 20 h / 20 °C / Molecular sieve
5: hydrogenchloride / 1,4-dioxane / 2 h / 80 °C
With
pyridine; hydrogenchloride; water; oxygen; copper diacetate; triethylamine;
toluene-4-sulfonic acid;
In
1,4-dioxane; dichloromethane; toluene;
![tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide](/Databaselist/images/loading.webp)
