tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide

Base Information

Chemical Name:tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide
CAS No.:1363593-73-0
Molecular Formula:C₂₂H₂₃N₃O₇S
Molecular Weight:473.507
Hs Code.:

Synonyms:tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide

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Chemical Property of tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide

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Technology Process of tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide

There total 12 articles about tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58599-05-6
3-(5-Methyl-[1,2,4]oxadiazol-3-yl)phenol

: 1363593-72-9
[2-(tert-butoxycarbonyl)-1,1-dioxido-3,4-dihydro-2H-5,1,2-benzoxathiazepin-8-yl]boronic acid

: 1363593-73-0
tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide

Guidance literature:: With pyridine; oxygen; copper diacetate; In dichloromethane; at 20 ℃; for 20h; Molecular sieve;

Reference yield:

: 873-62-1
m-cyanophenol

: 1363593-73-0
tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; triethylamine / dimethyl sulfoxide / 16 h / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: toluene-4-sulfonic acid / toluene / 12 h / Reflux

4: hydrogenchloride; water / 1.5 h / Reflux

5: pyridine; copper diacetate; oxygen / dichloromethane / 20 h / 20 °C / Molecular sieve

With pyridine; hydrogenchloride; hydroxylamine hydrochloride; water; oxygen; copper diacetate; triethylamine; toluene-4-sulfonic acid; In dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 1363593-67-2
5-bromo-N-(2-chloroethyl)-2-methoxybenzenesulphonamide

: 1363593-73-0
tert-butyl 8-[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenoxy]-3,4-dihydro-2H-5,1,2-benzoxathiazepine-2-carboxylate 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: boron tribromide / dichloromethane / 0.5 h / 20 °C

1.2: Cooling with ice

2.1: triethylamine / dimethylaminopyridine / dichloromethane / 20 °C

3.1: potassium carbonate; ethanol / potassium iodide / 18 h / Reflux

4.1: dmap / dichloromethane / 20 °C

5.1: n-butyllithium / tetrahydrofuran / 2 h / -65 - 20 °C

5.2: Cooling with ice

6.1: pyridine; copper diacetate; oxygen / dichloromethane / 20 h / 20 °C / Molecular sieve

With pyridine; n-butyllithium; ethanol; oxygen; copper diacetate; boron tribromide; potassium carbonate; triethylamine; dmap; potassium iodide; In tetrahydrofuran; dichloromethane;