(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester

Base Information

• Chemical Name: (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester
• CAS No.: 204187-39-3
• Molecular Formula: C₂₀H₂₇NO₃
• Molecular Weight: 329.439
• Mol file: 204187-39-3.mol

Synonyms:(S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester

Chemical Property of (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester

There total 3 articles about (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzylsuccinic acid (36092-42-9,884-33-3) → (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester (204187-39-3)

Guidance literature:

Multi-step reaction with 4 steps

2: 1.) SOCl₂, Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, RT, overnight

3: 80 percent / CH₂Cl₂ / 0 - 20 °C

4: 100 percent / HCl

With hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1248/cpb.46.337

Reference yield:

(2S)-benzylsuccinic acid (3972-36-9,884-33-3) → (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester (204187-39-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) SOCl₂, Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, RT, overnight

2: 80 percent / CH₂Cl₂ / 0 - 20 °C

3: 100 percent / HCl

With hydrogenchloride; thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1248/cpb.46.337

Reference yield:

(S)-2-Benzyl-succinic acid bis-(4-nitro-phenyl) ester (157060-06-5) → (S)-2-Benzyl-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid methyl ester (204187-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / HCl

With hydrogenchloride; In dichloromethane;

DOI:10.1248/cpb.46.337

upstream raw materials:

2-benzylsuccinic acid

(2S)-benzylsuccinic acid

(S)-2-Benzyl-succinic acid bis-(4-nitro-phenyl) ester

Downstream raw materials:

mitiglinide