2-methoxy-3-<(4-methoxyphenyl)amino>-5-hydroxy-γ-valerolactone

Base Information

• Chemical Name: 2-methoxy-3-<(4-methoxyphenyl)amino>-5-hydroxy-γ-valerolactone
• CAS No.: 103174-07-8
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.282
• Mol file: 103174-07-8.mol

Synonyms:2-methoxy-3-<(4-methoxyphenyl)amino>-5-hydroxy-γ-valerolactone

Chemical Property of 2-methoxy-3-<(4-methoxyphenyl)amino>-5-hydroxy-γ-valerolactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-3-<(4-methoxyphenyl)amino>-5-hydroxy-γ-valerolactone

There total 3 articles about 2-methoxy-3-<(4-methoxyphenyl)amino>-5-hydroxy-γ-valerolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(3R,4S)-cis-1-(p-anisyl)-3-methoxy-4-<(S)-2,2-dimethyl-1,3-dioxolan-4-yl>azetidin-2-one (103174-00-1) → 2-methoxy-3-<(4-methoxyphenyl)amino>-5-hydroxy-γ-valerolactone (103174-07-8)

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; water; at 50 ℃; for 0.0333333h; regioselective reaction; Microwave irradiation;

Reference yield:

N-(p-anisyl)-4-<(S)-2',2'-dimethyl-1',3'-dioxolan-4'-yl>-methylene-imine (103239-04-9) → 2-methoxy-3-<(4-methoxyphenyl)amino>-5-hydroxy-γ-valerolactone (103174-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / triethylamine / CH₂Cl₂ / -20 deg C to r.t., overnight

2: 64 percent / trifluoracetic acid (90percent) / 12 h / Heating

With triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

4-methoxy-aniline (104-94-9) → 2-methoxy-3-<(4-methoxyphenyl)amino>-5-hydroxy-γ-valerolactone (103174-07-8)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether / 1 h / 0 °C

2: 54 percent / triethylamine / CH₂Cl₂ / -20 deg C to r.t., overnight

3: 64 percent / trifluoracetic acid (90percent) / 12 h / Heating

With triethylamine; trifluoroacetic acid; In diethyl ether; dichloromethane;

upstream raw materials:

(3R,4S)-cis-1-(p-anisyl)-3-methoxy-4-<(S)-2,2-dimethyl-1,3-dioxolan-4-yl>azetidin-2-one

N-(p-anisyl)-4-<(S)-2',2'-dimethyl-1',3'-dioxolan-4'-yl>-methylene-imine

4-methoxy-aniline

Downstream raw materials:

Acetic acid (3S,4S,5R,6S)-6-acetoxy-5-methoxy-4-(4-methoxy-phenylamino)-tetrahydro-pyran-3-yl ester