1H-INDOLE-2-CARBOXYLIC ACID, 3-BROMO-5-METHOXY-, ETHYL ESTER

Base Information

• Chemical Name: 1H-INDOLE-2-CARBOXYLIC ACID, 3-BROMO-5-METHOXY-, ETHYL ESTER
• CAS No.: 92622-96-3
• Molecular Formula: C12H12 Br N O3
• Molecular Weight: 298.136
• Hs Code.: 2933990090
• Mol file: 92622-96-3.mol

Synonyms:1H-INDOLE-2-CARBOXYLIC ACID, 3-BROMO-5-METHOXY-, ETHYL ESTER

Chemical Property of 1H-INDOLE-2-CARBOXYLIC ACID, 3-BROMO-5-METHOXY-, ETHYL ESTER

Chemical Property:

• PSA: 51.32000
• LogP: 3.11570

Purity/Quality:

99% ^*data from raw suppliers

3-BROMO-5-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-INDOLE-2-CARBOXYLIC ACID, 3-BROMO-5-METHOXY-, ETHYL ESTER

There total 3 articles about 1H-INDOLE-2-CARBOXYLIC ACID, 3-BROMO-5-METHOXY-, ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 5-methoxy-1H-indole-2-carboxylate (4792-58-9) → ethyl 3-bromo-5-methoxy-1H-indole-2-carboxylate (92622-96-3)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 ℃; for 30h;

Reference yield: 78.0%

ethyl 5-methoxy-1H-indole-2-carboxylate (4792-58-9) → ethyl 3,4-dibromo-5-methoxy-1H-indole-2-carboxylate (30933-70-1) + ethyl 3-bromo-5-methoxy-1H-indole-2-carboxylate (92622-96-3) + ethyl 4-bromo-5-methoxy-1H-indole-2-carboxylate (30933-69-8) + ethyl 3,6-dibromo-5-methoxyindole-2-carboxylate

Guidance literature:

With bromine; In acetic acid; for 1h; Product distribution; Mechanism; Ambient temperature; other methoxy derivatives of ethyl indole-2-acrboxylate; pyridinium bromide perbromide or N-bromosuccinimide (NBS) as bromination agent; var. solvents, temperatures and reaction times;

Reference yield:

ethyl 5-methoxy-1H-indole-2-carboxylate (4792-58-9) → ethyl 3,4-dibromo-5-methoxy-1H-indole-2-carboxylate (30933-70-1) + ethyl 3-bromo-5-methoxy-1H-indole-2-carboxylate (92622-96-3) + ethyl 4-bromo-5-methoxy-1H-indole-2-carboxylate (30933-69-8)

Guidance literature:

With bromine; In acetic acid; for 0.00277778h; Product distribution; 30 s, 24 h or 24 h with sodium acetate buffer;

DOI:10.1021/jo00199a004

upstream raw materials:

ethyl 5-methoxy-1H-indole-2-carboxylate

Downstream raw materials:

4-bromo-5-methoxy-1H-indole-2-carboxylic acid

5-methoxyindole-4-carboxaldehyde

ethyl 4-bromo-5-methoxy-1H-indole-2-carboxylate