1-phenyl-3-(4-methoxyphenyl)-5-(4-(2-ethanoloxy)phenyl)-1H-pyrazole

Base Information

• Chemical Name: 1-phenyl-3-(4-methoxyphenyl)-5-(4-(2-ethanoloxy)phenyl)-1H-pyrazole
• CAS No.: 1462341-44-1
• Molecular Formula: C₂₄H₂₂N₂O₃
• Molecular Weight: 386.45
• Mol file: 1462341-44-1.mol

Synonyms:1-phenyl-3-(4-methoxyphenyl)-5-(4-(2-ethanoloxy)phenyl)-1H-pyrazole

Chemical Property of 1-phenyl-3-(4-methoxyphenyl)-5-(4-(2-ethanoloxy)phenyl)-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-3-(4-methoxyphenyl)-5-(4-(2-ethanoloxy)phenyl)-1H-pyrazole

There total 4 articles about 1-phenyl-3-(4-methoxyphenyl)-5-(4-(2-ethanoloxy)phenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C22H18N2O2 (1462341-37-2) + 2-chloro-ethanol (107-07-3) → 1-phenyl-3-(4-methoxyphenyl)-5-(4-(2-ethanoloxy)phenyl)-1H-pyrazole (1462341-44-1)

Guidance literature:

With triethylamine; In acetone; for 4h; Reflux;

DOI:10.13005/ojc/290223

Reference yield:

α-4-hydroxy phenyl β-4'methoxy benzoyl ethylene (69704-15-0) → 1-phenyl-3-(4-methoxyphenyl)-5-(4-(2-ethanoloxy)phenyl)-1H-pyrazole (1462341-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; hydrogenchloride / water / Reflux

2: triethylamine / acetone / 4 h / Reflux

With hydrogenchloride; acetic acid; triethylamine; In water; acetone;

DOI:10.13005/ojc/290223

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 1-phenyl-3-(4-methoxyphenyl)-5-(4-(2-ethanoloxy)phenyl)-1H-pyrazole (1462341-44-1)

Guidance literature:

Multi-step reaction with 3 steps

1: Alkaline conditions

2: acetic acid; hydrogenchloride / water / Reflux

3: triethylamine / acetone / 4 h / Reflux

With hydrogenchloride; acetic acid; triethylamine; In water; acetone; 1: |Claisen-Schmidt Condensation;

DOI:10.13005/ojc/290223

upstream raw materials:

C₂₂H₁₈N₂O₂

2-chloro-ethanol

α-4-hydroxy phenyl β-4'methoxy benzoyl ethylene

4-hydroxy-benzaldehyde