N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Base Information

Chemical Name:N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester
CAS No.:86778-73-6
Molecular Formula:C₂₈H₃₆N₂O₇
Molecular Weight:512.603
Hs Code.:

Synonyms:N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

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Technology Process of N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

There total 5 articles about N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 86778-72-5
N-<4-(4-hydroxyphenyl)butyryl>-L-proline

: 16024-44-5
DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester hydrochloride

: 86778-73-6
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Guidance literature:: With N-Ethylmaleimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 25 ℃; for 72h; pH 7.0-7.5;
DOI:10.1021/jm00369a017

Reference yield:

: 7021-11-6
4-(4-hydroxyphenyl)butanoic acid

: 86778-73-6
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

2: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

3: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

With N-Ethylmaleimide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017

Reference yield:

: 22320-10-1
methyl 4-(4-hydroxyphenyl)butanoate

: 86778-73-6
N-<4-(4-hydroxyphenyl)butyryl>-L-prolyl-DL-α-methyl-3,4-dimethoxyphenylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 48percent HBr / acetic acid / Heating

2: 83 percent / HOBt, NEM, DCC / tetrahydrofuran; dimethylformamide / 17 h / 25 °C / pH 7.0-7.5

3: 100 percent / H₂ / 10percent Pd/C (wet with H₂O) / ethanol / 3 h / 3102.9 Torr

4: 100 percent / HOBt, NEM, DCC / tetrahydrofuran / 72 h / 25 °C / pH 7.0-7.5

With N-Ethylmaleimide; hydrogen bromide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on carbon; In tetrahydrofuran; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00369a017