1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one

Base Information

Chemical Name:1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one
CAS No.:1281816-32-7
Molecular Formula:C₂₇H₃₀ClNO
Molecular Weight:419.994
Hs Code.:

Synonyms:1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one

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Chemical Property of 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one

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Technology Process of 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one

There total 6 articles about 1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.3%

: 2051-49-2
n-hexanoic anhydride

: 133111-56-5
6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine

: 1281816-32-7
1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.01.002

Reference yield:

: 1003-85-6
5.5-dimethyl-1,3,2-dioxathiane-2-oxide

: 1281816-32-7
1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 36 h / 100 °C

2.1: pyridine; thionyl chloride / 0 °C

3.1: diethyl ether / 2 h / Reflux

3.2: 3 h / Reflux

4.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C

5.1: boron trifluoride diethyl etherate / diethyl ether / 20 °C / Inert atmosphere

With pyridine; thionyl chloride; boron trifluoride diethyl etherate; sodium hydrogencarbonate; In diethyl ether; ethanol; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.01.002

Reference yield:

: 103804-80-4
3,3-dimethyl-4-hydroxy butyronitrile

: 1281816-32-7
1-(2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl)hexan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; thionyl chloride / 0 °C

2.1: diethyl ether / 2 h / Reflux

2.2: 3 h / Reflux

3.1: sodium hydrogencarbonate / ethanol / 36 h / 20 °C

4.1: boron trifluoride diethyl etherate / diethyl ether / 20 °C / Inert atmosphere

With pyridine; thionyl chloride; boron trifluoride diethyl etherate; sodium hydrogencarbonate; In diethyl ether; ethanol;
DOI:10.1016/j.ejmech.2011.01.002