3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile

Base Information

Chemical Name:3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile
CAS No.:1426328-59-7
Molecular Formula:C₁₆H₁₂N₄O
Molecular Weight:276.297
Hs Code.:

Synonyms:3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile

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Chemical Property of 3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile

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Technology Process of 3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile

There total 11 articles about 3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.9%

: C₂₁H₂₀N₄O₃

: 1426328-59-7
3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 25 ℃; for 24h;

Reference yield: 62.0%

: 557-21-1
zinc(II) cyanide

: 1426329-35-2
8-amino-4-(3-bromophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one

: 1426328-59-7
3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile

Guidance literature:: zinc(II) cyanide; 8-amino-4-(3-bromophenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one; With ISOPROPYLAMIDE; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; at 20 ℃; for 0.25h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; at 110 ℃; for 12.25h;

Reference yield:

: 99-56-9
4-Nitrophenylene-1,2-diamine

: 1426328-59-7
3-(8-amino-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 12 h / 110 °C / Inert atmosphere

2.1: iron; ammonium chloride / ethanol; water / 1 h / 90 °C

3.1: ISOPROPYLAMIDE; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc / 0.25 h / 20 °C / Inert atmosphere

3.2: 12.25 h / 110 °C

With ISOPROPYLAMIDE; iron; ammonium chloride; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In ethanol; water;