methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate

Base Information

Chemical Name:methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate
CAS No.:1239891-53-2
Molecular Formula:C₃₆H₅₂N₄O₆
Molecular Weight:636.832
Hs Code.:

Synonyms:methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate

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Chemical Property of methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate

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Technology Process of methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate

There total 5 articles about methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1239891-52-1
C₃₇H₅₅NO₉S

: 1239891-53-2
methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate

Guidance literature:: With sodium azide; In 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at 60 ℃; for 7.5h;
DOI:10.1039/b924176k

Reference yield:

: 1239891-51-0
C₃₆H₅₃NO₇

: 1239891-53-2
methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

2: sodium azide / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 7.5 h / 60 °C

With dmap; sodium azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 1: Mitsunobu reaction;
DOI:10.1039/b924176k

Reference yield:

: 3749-87-9
methyl 3α,7α-diacetoxy-12α-hydroxy cholanate

: 1239891-53-2
methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 10.5 h / 20 °C / Inert atmosphere

2: hydrogenchloride; water / methanol / 6 h / 20 °C

3: dmap; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

4: sodium azide / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 7.5 h / 60 °C

With hydrogenchloride; dmap; sodium azide; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane; 3: Mitsunobu reaction;
DOI:10.1039/b924176k