Technology Process of methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate
There total 5 articles about methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide;
In
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone;
at 60 ℃;
for 7.5h;
DOI:10.1039/b924176k
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dmap; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere
2: sodium azide / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 7.5 h / 60 °C
With
dmap; sodium azide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone;
1: Mitsunobu reaction;
DOI:10.1039/b924176k
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 10.5 h / 20 °C / Inert atmosphere
2: hydrogenchloride; water / methanol / 6 h / 20 °C
3: dmap; triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere
4: sodium azide / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 7.5 h / 60 °C
With
hydrogenchloride; dmap; sodium azide; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane;
3: Mitsunobu reaction;
DOI:10.1039/b924176k
