methyl 3α-(4,5-dihydro-1H-imidazol-2-yl)-7α-acetoxy-12α[4-(N,N-dimethylamino)benzoyloxy]-5β-cholan-24-oate hydrochloride

Base Information

• Chemical Name: methyl 3α-(4,5-dihydro-1H-imidazol-2-yl)-7α-acetoxy-12α[4-(N,N-dimethylamino)benzoyloxy]-5β-cholan-24-oate hydrochloride
• CAS No.: 1239891-49-6
• Molecular Formula: C₃₉H₅₈N₄O₆*ClH
• Molecular Weight: 715.374
• Mol file: 1239891-49-6.mol

Synonyms:methyl 3α-(4,5-dihydro-1H-imidazol-2-yl)-7α-acetoxy-12α[4-(N,N-dimethylamino)benzoyloxy]-5β-cholan-24-oate hydrochloride

Chemical Property of methyl 3α-(4,5-dihydro-1H-imidazol-2-yl)-7α-acetoxy-12α[4-(N,N-dimethylamino)benzoyloxy]-5β-cholan-24-oate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3α-(4,5-dihydro-1H-imidazol-2-yl)-7α-acetoxy-12α[4-(N,N-dimethylamino)benzoyloxy]-5β-cholan-24-oate hydrochloride

There total 8 articles about methyl 3α-(4,5-dihydro-1H-imidazol-2-yl)-7α-acetoxy-12α[4-(N,N-dimethylamino)benzoyloxy]-5β-cholan-24-oate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C39H58N4O6 (1239891-55-4) → methyl 3α-(4,5-dihydro-1H-imidazol-2-yl)-7α-acetoxy-12α[4-(N,N-dimethylamino)benzoyloxy]-5β-cholan-24-oate hydrochloride (1239891-49-6)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1039/b924176k

Reference yield:

C37H55NO9S (1239891-52-1) → methyl 3α-(4,5-dihydro-1H-imidazol-2-yl)-7α-acetoxy-12α[4-(N,N-dimethylamino)benzoyloxy]-5β-cholan-24-oate hydrochloride (1239891-49-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium azide / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 7.5 h / 60 °C

2: acetic acid; zinc / 1 h / 20 °C

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4: hydrogenchloride / water

With hydrogenchloride; sodium azide; sodium hydrogencarbonate; acetic acid; zinc; In 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; water; N,N-dimethyl-formamide;

DOI:10.1039/b924176k

Reference yield:

methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate (1239891-53-2) → methyl 3α-(4,5-dihydro-1H-imidazol-2-yl)-7α-acetoxy-12α[4-(N,N-dimethylamino)benzoyloxy]-5β-cholan-24-oate hydrochloride (1239891-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; zinc / 1 h / 20 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3: hydrogenchloride / water

With hydrogenchloride; sodium hydrogencarbonate; acetic acid; zinc; In water; N,N-dimethyl-formamide;

DOI:10.1039/b924176k

upstream raw materials:

C₃₇H₅₅NO₉S

methyl 3α-azido-7α-acetoxy-12α-[4-(N,N-dimethylamino)-benzoyloxy]-5β-cholan-24-oate

C₃₆H₅₄N₂O₆

C₃₉H₅₈N₄O₆