toluene-4-sulfonic acid 3-(3,5-bis-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester

Base Information

Chemical Name:toluene-4-sulfonic acid 3-(3,5-bis-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester
CAS No.:442200-93-3
Molecular Formula:C₄₂H₆₆N₄O₁₂S
Molecular Weight:851.072
Hs Code.:

toluene-4-sulfonic acid 3-(3,5-bis-{[<i>tert</i>-butoxycarbonyl-(2-<i>tert</i>-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester

Synonyms:toluene-4-sulfonic acid 3-(3,5-bis-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester

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Chemical Property of toluene-4-sulfonic acid 3-(3,5-bis-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester

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Technology Process of toluene-4-sulfonic acid 3-(3,5-bis-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester

There total 6 articles about toluene-4-sulfonic acid 3-(3,5-bis-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 5469-66-9
propane-1,3-diol ditosylate

: 289910-01-6
{2-[tert-butoxycarbonyl-(3-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-5-hydroxy-benzyl)-amino]-ethyl}-carbamic acid tert-butyl ester

: 442200-93-3
toluene-4-sulfonic acid 3-(3,5-bis-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
DOI:10.1016/S0040-4020(02)00203-X

Reference yield:

: 61019-06-5
3,5-dimethylphenyl pivaloate

: 442200-93-3
toluene-4-sulfonic acid 3-(3,5-bis-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 16 h / Heating

2: 45 percent / iPr₂NEt / CH₂Cl₂ / 0.5 h / 20 °C

3: 78 percent / iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

4: 100 percent / 1.0 M NaOH / tetrahydrofuran; H₂O / 6 h / 60 °C

5: 76 percent / t-BuOK / dimethylformamide / 1.5 h / 20 °C

With sodium hydroxide; N-Bromosuccinimide; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00203-X

Reference yield:

: 108-68-9,50356-23-5
3,5-Dimethylphenol

: 442200-93-3
toluene-4-sulfonic acid 3-(3,5-bis-{[tert-butoxycarbonyl-(2-tert-butoxycarbonylamino-ethyl)-amino]-methyl}-phenoxy)-propyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / 4-dimethylaminopyridine; Et₃N / CH₂Cl₂ / 1 h / 20 °C

2: 58 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 16 h / Heating

3: 45 percent / iPr₂NEt / CH₂Cl₂ / 0.5 h / 20 °C

4: 78 percent / iPr₂NEt / CH₂Cl₂ / 3 h / 20 °C

5: 100 percent / 1.0 M NaOH / tetrahydrofuran; H₂O / 6 h / 60 °C

6: 76 percent / t-BuOK / dimethylformamide / 1.5 h / 20 °C

With dmap; sodium hydroxide; N-Bromosuccinimide; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00203-X